MetaCyc Pathway: hexitol fermentation to lactate, formate, ethanol and acetate in Dickeya dadantii 3937

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Reactions and Genes Norland
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Mannitol-1-phosphate 5-dehydrogenase:
D-mannitol 1-phosphate + NAD+→β-D-fructofuranose 6-phosphate + NADH + H+ (EC 1.1.1.17)
DDA3937_RS20975 -0.5
Sorbitol-6-phosphate 2-dehydrogenase:
D-sorbitol 6-phosphate + NAD+→keto-D-fructose 6-phosphate + NADH + H+ (EC 1.1.1.140)
No genes
Fructose-bisphosphatase:
β-D-fructofuranose 1,6-bisphosphate + H2O→β-D-fructofuranose 6-phosphate + phosphate (EC 3.1.3.11)
DDA3937_RS00860 -0.2
DDA3937_RS00885 +0.4
DDA3937_RS06650 +0.1
DDA3937_RS18575 -1.2
6-phosphofructokinase:
β-D-fructofuranose 6-phosphate + ATP→β-D-fructofuranose 1,6-bisphosphate + ADP + H+ (EC 2.7.1.11)
DDA3937_RS00845 +0.1
Fructose-bisphosphate aldolase:
β-D-fructofuranose 1,6-bisphosphate→glycerone phosphate + D-glyceraldehyde 3-phosphate (EC 4.1.2.13)
DDA3937_RS18510 N.D.
Triose-phosphate isomerase (in reverse):
glycerone phosphate→D-glyceraldehyde 3-phosphate (EC 5.3.1.1)
DDA3937_RS00865 -0.3
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating):
D-glyceraldehyde 3-phosphate + NAD+ + phosphate→3-phospho-D-glyceroyl phosphate + NADH + H+ (EC 1.2.1.12)
DDA3937_RS10265 N.D.
Phosphoglycerate kinase (in reverse):
3-phospho-D-glyceroyl phosphate + ADP→3-phospho-D-glycerate + ATP (EC 2.7.2.3)
DDA3937_RS18515 N.D.
3-phospho-D-glycerate→2-phospho-D-glycerate (EC 5.4.2.12)
DDA3937_RS06570 N.D.
DDA3937_RS18440 +0.4
3-phospho-D-glycerate→2-phospho-D-glycerate (EC 5.4.2.11)
DDA3937_RS06570 N.D.
Phosphopyruvate hydratase:
2-phospho-D-glycerate→phosphoenolpyruvate + H2O (EC 4.2.1.11)
DDA3937_RS17000 N.D.
Pyruvate kinase (in reverse):
phosphoenolpyruvate + ADP + H+→pyruvate + ATP (EC 2.7.1.40)
DDA3937_RS10125 -0.1
DDA3937_RS12740 -0.1
L-lactate dehydrogenase (in reverse):
pyruvate + NADH + H+→(S)-lactate + NAD+ (EC 1.1.1.27)
DDA3937_RS07200 +0.1
DDA3937_RS07205 -0.2
DDA3937_RS12255 -0.3
DDA3937_RS12260 -0.1
Pyruvate, water dikinase:
pyruvate + ATP + H2O→phosphoenolpyruvate + AMP + 2 H+ + phosphate (EC 2.7.9.2)
DDA3937_RS12805 -1.5
Formate C-acetyltransferase (in reverse):
pyruvate + coenzyme A→acetyl-CoA + formate (EC 2.3.1.54)
DDA3937_RS09650 -1.3
DDA3937_RS09655 -1.3
DDA3937_RS15785 +0.3
Acetaldehyde dehydrogenase (acetylating) (in reverse):
acetyl-CoA + NADH + H+→acetaldehyde + coenzyme A + NAD+ (EC 1.2.1.10)
DDA3937_RS10360 +0.1
DDA3937_RS16335 +0.4
Phosphate acetyltransferase:
acetyl-CoA + phosphate→acetyl phosphate + coenzyme A (EC 2.3.1.8)
DDA3937_RS14385 -2.2
Acetate kinase (in reverse):
acetyl phosphate + ADP→acetate + ATP (EC 2.7.2.1; 2.7.2.15)
DDA3937_RS10145 -0.3
DDA3937_RS14380 -1.2
Alcohol dehydrogenase (in reverse):
acetaldehyde + NADH + H+→ethanol + NAD+ (EC 1.1.1.1)
DDA3937_RS01315 -0.0
DDA3937_RS03640 +0.3
DDA3937_RS09325 +0.2
DDA3937_RS10360 +0.1
DDA3937_RS11900 +0.1
DDA3937_RS17845 -0.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information