MetaCyc Pathway: pyruvate fermentation to isobutanol (engineered) in Dickeya dadantii 3937

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Reactions and Genes M9+glycerol
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Acetolactate synthase:
2 pyruvate + H+→(S)-2-acetolactate + CO2 (EC 2.2.1.6)
DDA3937_RS03235 +0.0
DDA3937_RS18100 +0.1
DDA3937_RS18105 -0.0
DDA3937_RS18170 -1.5
DDA3937_RS18175 -0.5
DDA3937_RS20165 -0.3
DDA3937_RS20170 -0.3
Ketol-acid reductoisomerase (in reverse):
(S)-2-acetolactate + NADPH + H+→(2R)-2,3-dihydroxy-3-methylbutanoate + NADP+ (EC 1.1.1.86)
DDA3937_RS20130 -3.0
Dihydroxy-acid dehydratase:
(2R)-2,3-dihydroxy-3-methylbutanoate→3-methyl-2-oxobutanoate + H2O (EC 4.2.1.9)
DDA3937_RS20155 -4.1
Branched-chain-2-oxoacid decarboxylase:
3-methyl-2-oxobutanoate + H+→isobutanal + CO2 (EC 4.1.1.72)
No genes
Alcohol dehydrogenase (in reverse):
isobutanal + NADH + H+→isobutanol + NAD+ (EC 1.1.1.1)
DDA3937_RS01315 -0.3
DDA3937_RS03640 +0.4
DDA3937_RS09325 -0.2
DDA3937_RS10360 -0.0
DDA3937_RS11900 +0.1
DDA3937_RS17845 +0.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information