MetaCyc Pathway: L-tryptophan degradation V (side chain pathway) in Escherichia coli BW25113

Add experiment(s):


Reactions and Genes LB Anaerobic with Furaltadone 0.000015625 mM
remove
L-tryptophan + dioxygen + H+ + H2O→(indol-3-yl)acetaldehyde + ammonium + CO2 + hydrogen peroxide
No genes
Tryptophan 2'-dioxygenase:
(indol-3-yl)acetaldehyde + dioxygen + H2O→(2R)-2-hydroxy-2-(indol-3-yl)acetaldehyde + hydrogen peroxide (EC 1.13.99.3)
No genes
Aldehyde dehydrogenase (NAD(P)(+)):
(indol-3-yl)acetaldehyde + NAD(P)+ + H2O→(indol-3-yl)acetate + NAD(P)H + 2 H+ (EC 1.2.1.5)
No genes
(indol-3-yl)acetaldehyde + NAD(P)H + H+→(indol-3-yl)ethanol + NAD(P)+
No genes
(2R)-2-hydroxy-2-(indol-3-yl)acetaldehyde + dioxygen→(indol-3-yl)glyoxal + hydrogen peroxide (EC 1.1.3.M5)
No genes
Tryptophan 2'-dioxygenase:
(indol-3-yl)acetate + dioxygen + H2O→(2R)-2-hydroxy-2-(indol-3-yl)acetate + hydrogen peroxide (EC 1.13.99.3)
No genes
Tryptophan 2'-dioxygenase:
(indol-3-yl)ethanol + dioxygen + H2O→(indol-3-yl)glycol + hydrogen peroxide (EC 1.13.99.3)
No genes
Alcohol dehydrogenase (in reverse):
(2R)-2-hydroxy-2-(indol-3-yl)acetaldehyde + NADH + H+→(indol-3-yl)glycol + NAD+ (EC 1.1.1.1)
b0325 (yahK) +0.2
b0356 (frmA) -0.1
b1241 (adhE) -0.6
b1478 (adhP) -0.4
b3253 (yhdH) -4.6
b4269 (yjgB) +0.3
b3589 (yiaY) +0.1
(2R)-2-hydroxy-2-(indol-3-yl)acetaldehyde + an oxidized electron carrier + H2O→(2R)-2-hydroxy-2-(indol-3-yl)acetate + a reduced two electron carrier + H+
No genes
(2R)-2-hydroxy-2-(indol-3-yl)acetate + dioxygen→2-(indol-3-yl)-2-oxoacetate + hydrogen peroxide (EC 1.1.3.M5)
No genes
(indol-3-yl)glycol + dioxygen→2-hydroxy-1-(indol-3-yl)ethanone + hydrogen peroxide (EC 1.1.3.M5)
No genes
(indol-3-yl)glyoxal + NADH + H+→2-hydroxy-1-(indol-3-yl)ethanone + NAD+
No genes
(indol-3-yl)glyoxal + an oxidized electron carrier + H2O→2-(indol-3-yl)-2-oxoacetate + a reduced two electron carrier + H+
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information