MetaCyc Pathway: pyruvate fermentation to ethanol III in Escherichia coli BW25113
| Reactions and Genes | LB Anaerobic with Nitrofurantoin 0.000015625 mM |
|---|---|
| remove | |
| Pyruvate synthase: pyruvate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster→acetyl-CoA + CO2 + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster (EC 1.2.7.1) | |
| b1378 (ydbK) | +0.3 |
| Acetaldehyde dehydrogenase (acetylating) (in reverse): acetyl-CoA + NADH + H+→acetaldehyde + coenzyme A + NAD+ (EC 1.2.1.10) | |
| b0351 (mhpF) | -0.1 |
| b1241 (adhE) | -0.6 |
| b2455 (eutE) | -0.1 |
| Alcohol dehydrogenase (in reverse): acetaldehyde + NADH + H+→ethanol + NAD+ (EC 1.1.1.1) | |
| b0325 (yahK) | +0.2 |
| b0356 (frmA) | -0.1 |
| b1241 (adhE) | -0.6 |
| b1478 (adhP) | -0.3 |
| b3253 (yhdH) | -2.3 |
| b4269 (yjgB) | -0.1 |
| b3589 (yiaY) | +0.1 |
Links:
- Pathway details at MetaCyc
- Fitness data for 10 genes
- All MetaCyc pathways for Escherichia coli BW25113
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information