MetaCyc Pathway: superpathway of coenzyme A biosynthesis II (plants) in Pseudomonas putida KT2440

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Reactions and Genes LB 0.1x with 55.5 mM D-Glucose; pH 4.6
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3-methyl-2-oxobutanoate hydroxymethyltransferase:
3-methyl-2-oxobutanoate + a 5,10-methylenetetrahydrofolate + H2O→2-dehydropantoate + a tetrahydrofolate (EC 2.1.2.11)
PP_4699 -0.6
Propionate--CoA ligase:
propanoate + ATP + coenzyme A→propanoyl-CoA + AMP + diphosphate (EC 6.2.1.17)
PP_2351 -0.0
PP_4487 -0.3
PP_4702 -0.0
2-dehydropantoate 2-reductase (in reverse):
2-dehydropantoate + NADPH + H+→(R)-pantoate + NADP+ (EC 1.1.1.169)
PP_1351 -0.1
PP_2325 -0.0
PP_2998 +0.0
PP_4678 -0.1
propanoyl-CoA + an oxidized electron-transfer flavoprotein + H+→acryloyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.1)
PP_4948 +0.1
acryloyl-CoA + H2O→3-hydroxypropanoyl-CoA (EC 4.2.1.116)
PP_2217 -1.8
3-hydroxyisobutyryl-CoA hydrolase:
3-hydroxypropanoyl-CoA + H2O→3-hydroxypropanoate + coenzyme A + H+ (EC 3.1.2.4)
PP_3491 -0.2
3-hydroxypropionate dehydrogenase:
3-hydroxypropanoate + NAD+→3-oxopropanoate + NADH + H+ (EC 1.1.1.59)
No genes
Beta-alanine--pyruvate transaminase:
3-oxopropanoate + L-alanine→β-alanine + pyruvate (EC 2.6.1.18)
PP_0596 +0.1
PP_3718 +0.1
PP_5182 -1.5
Pantoate--beta-alanine ligase:
β-alanine + (R)-pantoate + ATP→(R)-pantothenate + AMP + diphosphate + H+ (EC 6.3.2.1)
PP_4700 -3.1
Pantothenate kinase:
(R)-pantothenate + ATP→(R)-4'-phosphopantothenate + ADP + H+ (EC 2.7.1.33)
PP_0438 N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information