| Reactions and Genes | LB Anaerobic with Mecillinam 0.0000078125 mM |
|---|
| remove |
| a mature peptidoglycan (meso-DAP containing)→a mature peptidoglycan (meso-DAP containing) + GlcNAc-1,6-anhMurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala (EC 4.2.2.f) |
| b0211 (mltD) | +0.2 |
| b1193 (mltE) | N.D. |
| b2558 (mltF) | +0.0 |
| b2701 (mltB) | +0.4 |
| b2813 (mltA) | +0.0 |
| b2963 (mltC) | -0.0 |
| b4392 (slt) | +3.1 |
| GlcNAc-1,6-anhMurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala[out] + H+[out]→GlcNAc-1,6-anhMurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala[in] + H+[in] |
| b0433 (ampG) | -0.5 |
N-acetylmuramoyl-L-alanine amidase:
GlcNAc-1,6-anhMurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala + H2O→N-acetyl-β-D-glucosamine-1,6-anhydro-N-acetyl-β-D-muramate + L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanine (EC 3.5.1.28) |
| b0110 (ampD) | -0.8 |
| b0867 (ybjR) | -0.0 |
| b2435 (amiA) | -0.4 |
| b2817 (b2817) | +0.1 |
| b4169 (amiB) | -0.2 |
Beta-N-acetylhexosaminidase:
N-acetyl-β-D-glucosamine-1,6-anhydro-N-acetyl-β-D-muramate + H2O→1,6-anhydro-N-acetyl-β-D-muramate + N-acetyl-D-glucosamine (EC 3.2.1.52) |
| b1107 (nagZ) | +0.2 |
Muramoyltetrapeptide carboxypeptidase:
L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanine + H2O→L-alanyl-γ-D-glutamyl-meso-diaminopimelate + D-alanine (EC 3.4.17.13) |
| b1192 (ldcA) | -4.9 |
| 1,6-anhydro-N-acetyl-β-D-muramate + ATP + H2O→N-acetyl-D-muramate 6-phosphate + ADP + H+ (EC 2.7.1.170) |
| b1640 (ydhH) | +0.5 |
| N-acetyl-D-muramate 6-phosphate + H2O→N-acetyl-D-glucosamine 6-phosphate + (R)-lactate (EC 4.2.1.126) |
| b2428 (yfeU) | -0.0 |
N-acetylglucosamine-6-phosphate deacetylase:
N-acetyl-D-glucosamine 6-phosphate + H2O→D-glucosamine 6-phosphate + acetate (EC 3.5.1.25) |
| b0677 (nagA) | -0.2 |
Phosphoglucosamine mutase:
D-glucosamine 6-phosphate→α-D-glucosamine 1-phosphate (EC 5.4.2.10) |
| b3176 (glmM) | N.D. |
Glucosamine-1-phosphate N-acetyltransferase:
α-D-glucosamine 1-phosphate + acetyl-CoA→N-acetyl-α-D-glucosamine 1-phosphate + coenzyme A + H+ (EC 2.3.1.157) |
| b3730 (glmU) | N.D. |
UDP-N-acetylglucosamine diphosphorylase:
N-acetyl-α-D-glucosamine 1-phosphate + H+ + UTP→UDP-N-acetyl-α-D-glucosamine + diphosphate (EC 2.7.7.23) |
| b3730 (glmU) | N.D. |
UDP-N-acetylglucosamine 1-carboxyvinyltransferase:
UDP-N-acetyl-α-D-glucosamine + phosphoenolpyruvate→UDP-N-acetyl-α-D-glucosamine-enolpyruvate + phosphate (EC 2.5.1.7) |
| b3189 (murA) | N.D. |
| UDP-N-acetyl-α-D-glucosamine-enolpyruvate + NADPH + H+→UDP-N-acetyl-α-D-muramate + NADP+ (EC 1.3.1.98) |
| b3972 (murB) | N.D. |
| L-alanyl-γ-D-glutamyl-meso-diaminopimelate + UDP-N-acetyl-α-D-muramate + ATP→UDP-MurNAc-L-Ala-γ-D-Glu-meso-DAP + ADP + H+ + phosphate (EC 6.3.2.45) |
| b4233 (mpl) | -0.4 |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information