MetaCyc Pathway: TCA cycle III (animals) in Escherichia coli BW25113

Reactions and Genes	LB Anaerobic with Benzethonium chloride 0.00003125 mM
2-oxoglutarate + coenzyme A + NAD+→succinyl-CoA + CO2 + NADH (EC 1.2.1.105)
b0116 (lpd)	N.D.
Succinate--CoA ligase (ADP-forming) (in reverse): succinyl-CoA + ADP + phosphate→succinate + ATP + coenzyme A (EC 6.2.1.5)
b0728 (sucC)	-2.4
b0729 (sucD)	-1.3
Succinate--CoA ligase (GDP-forming) (in reverse): succinyl-CoA + GDP + phosphate→succinate + coenzyme A + GTP (EC 6.2.1.4)
No genes
Succinate dehydrogenase (ubiquinone): succinate[in] + a ubiquinone→fumarate[in] + a ubiquinol (EC 1.3.5.1)
b0723 (sdhA)	-0.2
b4154 (frdA)	+1.5
Fumarate hydratase (in reverse): fumarate + H2O→(S)-malate (EC 4.2.1.2)
b1611 (fumC)	+0.3
b1612 (fumA)	+0.5
b1675 (ydhZ)	+0.3
b2929 (yggD)	+0.8
b4122 (fumB)	+0.3
Malate dehydrogenase: (S)-malate + NAD+→oxaloacetate + NADH + H+ (EC 1.1.1.37; 1.1.1.38)
b0801 (ybiC)	-0.5
b1479 (sfcA)	-1.0
b3236 (mdh)	+1.2
Citrate (Si)-synthase: oxaloacetate + acetyl-CoA + H2O→citrate + coenzyme A + H+ (EC 2.3.3.1; 2.3.3.16; 2.3.3.3)
b0720 (gltA)	+0.8
Aconitate hydratase: citrate→cis-aconitate + H2O (EC 4.2.1.3)
b0118 (acnB)	+0.7
b0771 (ybhJ)	+0.2
b1276 (acnA)	-0.5
Aconitate hydratase: cis-aconitate + H2O→D-threo-isocitrate (EC 4.2.1.3)
b0118 (acnB)	+0.7
b0771 (ybhJ)	+0.2
b1276 (acnA)	-0.5
Isocitrate--homoisocitrate dehydrogenase: D-threo-isocitrate + NAD+→2-oxoglutarate + CO2 + NADH (EC 1.1.1.286; 1.1.1.41)
No genes

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information