MetaCyc Pathway: ADP-L-glycero-β-D-manno-heptose biosynthesis in Escherichia coli BW25113

Reactions and Genes	LB Aerobic with Trimethoprim 0.00000125 mM
D-sedoheptulose 7-phosphate→D-glycero-D-manno-heptose 7-phosphate (EC 5.3.1.28)
b0222 (lpcA)	-0.6
b3149 (yraO)	+2.0
D-glycero-D-manno-heptose 7-phosphate + ATP→D-glycero-β-D-manno-heptose 1,7-bisphosphate + ADP + H+ (EC 2.7.1.167)
b3052 (rfaE)	-1.0
D-glycero-β-D-manno-heptose 1,7-bisphosphate + H2O→D-glycero-β-D-manno-heptose 1-phosphate + phosphate (EC 3.1.3.82)
b0200 (gmhB)	-0.2
D-glycero-β-D-manno-heptose 1-phosphate + ATP + H+→ADP-D-glycero-β-D-manno-heptose + diphosphate (EC 2.7.7.70)
b3052 (rfaE)	-1.0
ADP-glyceromanno-heptose 6-epimerase: ADP-D-glycero-β-D-manno-heptose→ADP-L-glycero-β-D-manno-heptose (EC 5.1.3.20)
b3619 (rfaD)	-0.9

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information