MetaCyc Pathway: superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle in Escherichia coli BL21

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Reactions and Genes Bas30
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Diphosphate--fructose-6-phosphate 1-phosphotransferase:
β-D-fructofuranose 6-phosphate + diphosphate→β-D-fructofuranose 1,6-bisphosphate + H+ + phosphate (EC 2.7.1.90)
No genes
6-phosphofructokinase:
β-D-fructofuranose 6-phosphate + ATP→β-D-fructofuranose 1,6-bisphosphate + ADP + H+ (EC 2.7.1.11)
ECD_01692 +0.2
ECD_03801 -0.7
Fructose-bisphosphate aldolase:
β-D-fructofuranose 1,6-bisphosphate→glycerone phosphate + D-glyceraldehyde 3-phosphate (EC 4.1.2.13)
ECD_02025 -0.2
ECD_02756 N.D.
Triose-phosphate isomerase (in reverse):
glycerone phosphate→D-glyceraldehyde 3-phosphate (EC 5.3.1.1)
ECD_03804 N.D.
Glyceraldehyde-3-phosphate dehydrogenase (NADP(+)):
D-glyceraldehyde 3-phosphate + NADP+ + H2O→3-phospho-D-glycerate + NADPH + 2 H+ (EC 1.2.1.9)
No genes
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating):
D-glyceraldehyde 3-phosphate + NAD+ + phosphate→3-phospho-D-glyceroyl phosphate + NADH + H+ (EC 1.2.1.12)
ECD_01371 N.D.
ECD_01748 N.D.
Phosphoglycerate kinase (in reverse):
3-phospho-D-glyceroyl phosphate + ADP→3-phospho-D-glycerate + ATP (EC 2.7.2.3)
ECD_02757 N.D.
3-phospho-D-glycerate→2-phospho-D-glycerate (EC 5.4.2.12)
ECD_00708 +0.2
ECD_03470 -0.1
ECD_04271 +0.0
Phosphopyruvate hydratase:
2-phospho-D-glycerate→phosphoenolpyruvate + H2O (EC 4.2.1.11)
ECD_02624 N.D.
Pyruvate kinase (in reverse):
phosphoenolpyruvate + ADP + H+→pyruvate + ATP (EC 2.7.1.40)
ECD_01645 -0.1
ECD_01825 -0.0
pyruvate + a [pyruvate dehydrogenase E2 protein] N6-lipoyl-L-lysine + H+→a [pyruvate dehydrogenase E2 protein] N6-S-acetyldihydrolipoyl-L-lysine + CO2 (EC 1.2.1.104; 1.2.4.1)
ECD_00113 N.D.
a [pyruvate dehydrogenase E2 protein] N6-S-acetyldihydrolipoyl-L-lysine + coenzyme A→acetyl-CoA + a [pyruvate dehydrogenase E2 protein] N6-dihydrolipoyl-L-lysine (EC 1.2.1.104; 2.3.1.12)
ECD_00114 N.D.
Citrate (Si)-synthase:
oxaloacetate + acetyl-CoA + H2O→citrate + coenzyme A + H+ (EC 2.3.3.1; 2.3.3.16; 2.3.3.3)
ECD_00680 -0.8
a [pyruvate dehydrogenase E2 protein] N6-dihydrolipoyl-L-lysine + NAD+→a [pyruvate dehydrogenase E2 protein] N6-lipoyl-L-lysine + NADH + H+ (EC 1.2.1.104; 1.8.1.4)
ECD_00115 N.D.
ECD_00260 -0.0
Aconitate hydratase:
citrate→cis-aconitate + H2O (EC 4.2.1.3)
ECD_00117 N.D.
ECD_01253 -0.7
Aconitate hydratase:
cis-aconitate + H2O→D-threo-isocitrate (EC 4.2.1.3)
ECD_00117 N.D.
ECD_01253 -0.7
Isocitrate--homoisocitrate dehydrogenase:
D-threo-isocitrate + NAD+→2-oxoglutarate + CO2 + NADH (EC 1.1.1.286; 1.1.1.41)
No genes
2-oxoglutarate + coenzyme A + NAD+→succinyl-CoA + CO2 + NADH (EC 1.2.1.105)
ECD_00115 N.D.
Succinate--CoA ligase (ADP-forming) (in reverse):
succinyl-CoA + ADP + phosphate→succinate + ATP + coenzyme A (EC 6.2.1.5)
ECD_00687 -0.3
ECD_00688 -1.5
Succinate dehydrogenase (ubiquinone):
succinate[in] + an electron-transfer quinone→fumarate[in] + an electron-transfer quinol (EC 1.3.5.1)
No genes
Fumarate hydratase (in reverse):
fumarate + H2O→(S)-malate (EC 4.2.1.2)
ECD_01580 N.D.
ECD_01581 -0.2
ECD_01644 N.D.
ECD_02760 -0.0
ECD_03993 +0.0
Malate dehydrogenase:
(S)-malate + NAD+→oxaloacetate + NADH + H+ (EC 1.1.1.37; 1.1.1.38)
ECD_00768 -0.1
ECD_01437 N.D.
ECD_03096 -0.7

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information