MetaCyc Pathway: 2-methylpropene degradation in Escherichia coli BW25113

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Reactions and Genes Dodecanol (C)
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Alkene monooxygenase:
2-methylprop-1-ene + NADH + dioxygen + H+→1,2-epoxy-2-methylpropane + NAD+ + H2O (EC 1.14.13.69)
No genes
Soluble epoxide hydrolase:
1,2-epoxy-2-methylpropane + H2O→2-methylpropane-1,2-diol (EC 3.3.2.10)
No genes
2-methylpropane-1,2-diol + NAD+→2-hydroxy-2-methylpropanal + NADH + H+ (EC 1.1.1.400)
No genes
2-hydroxy-2-methylpropanal + NAD+ + H2O→2-hydroxy-2-methylpropanoate + NADH + 2 H+ (EC 1.2.1.98)
No genes
2-hydroxy-2-methylpropanoate + ATP + coenzyme A→2-hydroxy-2-methylpropanoyl-CoA + AMP + diphosphate (EC 6.2.1.M4)
No genes
2-hydroxy-2-methylpropanoyl-CoA→(S)-3-hydroxybutanoyl-CoA (EC 5.4.99.64)
No genes
3-hydroxyacyl-CoA dehydrogenase:
(S)-3-hydroxybutanoyl-CoA + NAD+→acetoacetyl-CoA + NADH + H+ (EC 1.1.1.35)
b2341 (yfcX) -0.2
b3846 (fadB) -1.4
Acetyl-CoA C-acyltransferase (in reverse):
acetoacetyl-CoA + coenzyme A→2 acetyl-CoA (EC 2.3.1.16; 2.3.1.9)
b1397 (paaJ) -0.1
b2224 (atoB) +0.1
b2342 (yfcY) -0.2
b2844 (yqeF) -0.0
b3845 (fadA) -0.5

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information