MetaCyc Pathway: fatty acid β-oxidation I (generic) in Escherichia coli BW25113

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Reactions and Genes Dodecanol (C)
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a 2,3,4-saturated fatty acid + ATP + coenzyme A→a 2,3,4-saturated fatty acyl CoA + AMP + diphosphate
No genes
Dodecenoyl-CoA isomerase:
a (3Z)-3-enoyl-CoA→a (2E)-2-enoyl-CoA
(EC 5.3.3.8)
b2341 (yfcX) -0.2
b3846 (fadB) -1.0
3-hydroxybutyryl-CoA epimerase:
a 2,3,4-saturated (3R)-3-hydroxyacyl-CoA→a 2,3,4-saturated (3S)-3-hydroxyacyl-CoA
(EC 5.1.2.3)
b2341 (yfcX) -0.2
b3846 (fadB) -1.0
a 2,3,4-saturated fatty acyl CoA + an oxidized electron-transfer flavoprotein + H+→a (2E)-2-enoyl-CoA + a reduced electron-transfer flavoprotein
b0221 (yafH) -1.2
Enoyl-CoA hydratase (in reverse):
a (2E)-2-enoyl-CoA + H2O→a 2,3,4-saturated (3S)-3-hydroxyacyl-CoA
(EC 4.2.1.17)
b1393 (paaF) N.D.
b1394 (paaG) +0.2
b2341 (yfcX) -0.2
b3846 (fadB) -1.0
3-hydroxyacyl-CoA dehydrogenase:
a 2,3,4-saturated (3S)-3-hydroxyacyl-CoA + NAD+→a 2,3,4-saturated 3-oxoacyl-CoA + NADH + H+
(EC 1.1.1.35)
b2341 (yfcX) -0.2
b3846 (fadB) -1.0
Acetyl-CoA C-acyltransferase (in reverse):
a 2,3,4-saturated 3-oxoacyl-CoA + coenzyme A→a 2,3,4-saturated fatty acyl CoA + acetyl-CoA
(EC 2.3.1.16)
b1397 (paaJ) +0.1
b2224 (atoB) -0.2
b2342 (yfcY) -0.3
b2844 (yqeF) -0.3
b3845 (fadA) -0.2

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information