MetaCyc Pathway: colanic acid building blocks biosynthesis in Pseudomonas putida KT2440

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Reactions and Genes D-Lysine 10 mM (C)
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Glucose-6-phosphate isomerase:
α-D-glucose 6-phosphate→β-D-fructofuranose 6-phosphate (EC 5.3.1.9)
PP_1808 +0.2
PP_4701 -0.7
Phosphoglucomutase (in reverse):
D-glucopyranose 6-phosphate→α-D-glucopyranose 1-phosphate (EC 5.4.2.2)
PP_1777 +1.7
PP_3578 -0.2
PP_4716 N.D.
PP_5288 +0.4
UTP-monosaccharide-1-phosphate uridylyltransferase:
α-D-glucopyranose 1-phosphate + H+ + UTP→UDP-α-D-glucose + diphosphate (EC 2.7.7.64; 2.7.7.9)
PP_3821 +0.8
Mannose-6-phosphate isomerase (in reverse):
β-D-fructofuranose 6-phosphate→D-mannopyranose 6-phosphate (EC 5.3.1.8)
PP_1277 +0.1
PP_2071 -0.1
PP_3568 N.D.
PP_4860 -1.3
Phosphomannomutase (in reverse):
D-mannopyranose 6-phosphate→α-D-mannose 1-phosphate (EC 5.4.2.8)
PP_1777 +1.7
PP_5288 +0.4
UDP-glucose 4-epimerase:
UDP-α-D-glucose→UDP-α-D-galactose (EC 5.1.3.2)
PP_0501 N.D.
PP_1800 +0.6
PP_1803 +0.6
PP_3129 +0.4
PP_3206 -0.3
UDP-glucose 6-dehydrogenase:
UDP-α-D-glucose + 2 NAD+ + H2O→UDP-α-D-glucuronate + 2 NADH + 3 H+ (EC 1.1.1.22)
PP_2926 +0.0
Mannose-1-phosphate guanylyltransferase:
α-D-mannose 1-phosphate + GTP + H+→GDP-α-D-mannose + diphosphate (EC 2.7.7.13)
PP_0406 +1.0
PP_1277 +0.1
GDP-mannose 4,6-dehydratase:
GDP-α-D-mannose→GDP-4-dehydro-α-D-rhamnose + H2O (EC 4.2.1.47)
PP_1799 +0.9
GDP-L-fucose synthase:
GDP-4-dehydro-α-D-rhamnose→GDP-4-dehydro-6-deoxy-β-L-galactose (EC 1.1.1.271)
No genes
GDP-L-fucose synthase (in reverse):
GDP-4-dehydro-6-deoxy-β-L-galactose + NADPH + H+→GDP-β-L-fucose + NADP+ (EC 1.1.1.271)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information