MetaCyc Pathway: L-tyrosine degradation I in Pseudomonas sp. RS175

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Reactions and Genes Quinic Acid (C)
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Aspartate transaminase:
L-tyrosine + 2-oxoglutarate→3-(4-hydroxyphenyl)pyruvate + L-glutamate (EC 2.6.1.1; 2.6.1.27; 2.6.1.5; 2.6.1.57)
PFR28_00188 -1.9
PFR28_00302 +0.1
PFR28_00800 -0.1
PFR28_00908 -0.6
PFR28_00984 -0.3
PFR28_01312 -1.3
PFR28_01605 -0.2
PFR28_01790 -0.1
PFR28_02468 +0.1
PFR28_02838 -1.8
PFR28_02973 -0.1
PFR28_03061 +0.1
PFR28_03135 -0.2
PFR28_04404 +0.0
PFR28_04508 -0.1
4-hydroxyphenylpyruvate dioxygenase:
3-(4-hydroxyphenyl)pyruvate + dioxygen→homogentisate + CO2 (EC 1.13.11.27)
PFR28_02475 -0.1
PFR28_03813 -1.3
Homogentisate 1,2-dioxygenase:
homogentisate + dioxygen→4-maleyl-acetoacetate + H+ (EC 1.13.11.5)
PFR28_00221 -0.2
Maleylacetoacetate isomerase:
4-maleyl-acetoacetate→4-fumaryl-acetoacetate (EC 5.2.1.2)
PFR28_00223 -0.1
Fumarylacetoacetase:
4-fumaryl-acetoacetate + H2O→acetoacetate + fumarate + H+ (EC 3.7.1.2)
PFR28_00222 -0.3

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information