MetaCyc Pathway: superpathway of glyoxylate cycle and fatty acid degradation in Pseudomonas simiae WCS417

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Reactions and Genes 2-Deoxy-D-Ribose (C)
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a 2,3,4-saturated fatty acid + ATP + coenzyme A→a 2,3,4-saturated fatty acyl CoA + AMP + diphosphate
No genes
Acyl-CoA oxidase:
a 2,3,4-saturated fatty acyl CoA + dioxygen→a (2E)-2-enoyl-CoA + hydrogen peroxide
(EC 1.3.3.6)
No genes
Enoyl-CoA hydratase (in reverse):
a (2E)-2-enoyl-CoA + H2O→a 2,3,4-saturated (3S)-3-hydroxyacyl-CoA
(EC 4.2.1.17)
PS417_07030 -0.1
PS417_07575 +0.5
PS417_08535 +0.0
PS417_10680 +0.2
PS417_11445 -0.0
PS417_12870 -0.4
PS417_13835 -0.2
PS417_13845 N.D.
PS417_21195 +0.1
PS417_21215 -0.1
PS417_22625 -0.1
3-hydroxyacyl-CoA dehydrogenase:
a 2,3,4-saturated (3S)-3-hydroxyacyl-CoA + NAD+→a 2,3,4-saturated 3-oxoacyl-CoA + NADH + H+
(EC 1.1.1.35)
PS417_07575 +0.5
PS417_21215 -0.1
PS417_26285 -0.6
Acetyl-CoA C-acyltransferase (in reverse):
a 2,3,4-saturated 3-oxoacyl-CoA + coenzyme A→a 2,3,4-saturated fatty acyl CoA + acetyl-CoA
(EC 2.3.1.16)
PS417_06710 +0.2
PS417_07580 N.D.
PS417_10515 -1.9
PS417_13855 +0.3
PS417_15175 N.D.
PS417_19210 -0.3
PS417_21220 +0.3
PS417_03145 +1.3
Citrate (Si)-synthase:
acetyl-CoA + oxaloacetate + H2O→citrate + coenzyme A + H+
(EC 2.3.3.1; 2.3.3.16; 2.3.3.3)
PS417_08870 N.D.
Aconitate hydratase:
citrate→cis-aconitate + H2O
(EC 4.2.1.3)
PS417_07515 +0.2
PS417_14990 N.D.
PS417_21070 -0.8
Aconitate hydratase:
cis-aconitate + H2O→D-threo-isocitrate
(EC 4.2.1.3)
PS417_07515 +0.2
PS417_14990 N.D.
PS417_21070 -0.8
Isocitrate lyase:
D-threo-isocitrate→glyoxylate + succinate
(EC 4.1.3.1)
PS417_16570 -0.1
Malate synthase:
acetyl-CoA + glyoxylate + H2O→(S)-malate + coenzyme A + H+
(EC 2.3.3.9)
PS417_26040 -0.9
Succinate dehydrogenase (ubiquinone):
succinate[in] + an electron-transfer quinone→fumarate[in] + an electron-transfer quinol
(EC 1.3.5.1)
PS417_08875 N.D.
PS417_08880 N.D.
PS417_08885 N.D.
PS417_08890 N.D.
Fumarate hydratase (in reverse):
fumarate + H2O→(S)-malate
(EC 4.2.1.2)
PS417_11625 +0.0
PS417_19200 +0.0
PS417_22635 N.D.
PS417_04305 +0.9
Malate dehydrogenase:
(S)-malate + NAD+→oxaloacetate + NADH + H+
(EC 1.1.1.37; 1.1.1.38)
No genes
Phosphoenolpyruvate carboxykinase (ATP):
oxaloacetate + ATP→phosphoenolpyruvate + ADP + CO2
(EC 4.1.1.49)
PS417_01210 +0.2

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information