MetaCyc Pathway: monolignol biosynthesis in Pseudomonas putida KT2440

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Reactions and Genes p-Coumaric (C)
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4-coumarate--CoA ligase:
4-coumarate + ATP + coenzyme A→(E)-4-coumaroyl-CoA + AMP + diphosphate (EC 6.2.1.12)
PP_3356 -2.3
Shikimate O-hydroxycinnamoyltransferase:
(E)-4-coumaroyl-CoA + shikimate→trans-5-O-(4-coumaroyl)shikimate + coenzyme A (EC 2.3.1.133)
No genes
Cinnamoyl-CoA reductase:
(E)-4-coumaroyl-CoA + NADPH + H+→4-coumaraldehyde + coenzyme A + NADP+ (EC 1.2.1.44)
No genes
Shikimate O-hydroxycinnamoyltransferase:
(E)-4-coumaroyl-CoA + L-quinate→trans-5-O-(4-coumaroyl)-D-quinate + coenzyme A (EC 2.3.1.133)
No genes
trans-5-O-(4-coumaroyl)-D-quinate + dioxygen + a reduced [NADPH-hemoprotein reductase]→chlorogenate + an oxidized [NADPH-hemoprotein reductase] + H2O (EC 1.14.14.96)
No genes
Cinnamyl-alcohol dehydrogenase (in reverse):
4-coumaraldehyde + NADPH + H+→4-coumaryl alcohol + NADP+ (EC 1.1.1.195)
No genes
trans-5-O-(4-coumaroyl)shikimate + dioxygen + a reduced [NADPH-hemoprotein reductase]→5-O-caffeoylshikimate + an oxidized [NADPH-hemoprotein reductase] + H2O (EC 1.14.14.96)
No genes
5-O-caffeoylshikimate + coenzyme A→(E)-caffeoyl-CoA + shikimate
No genes
chlorogenate + coenzyme A→(E)-caffeoyl-CoA + L-quinate
No genes
Caffeoyl-CoA O-methyltransferase:
(E)-caffeoyl-CoA + S-adenosyl-L-methionine→feruloyl-CoA + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.104)
No genes
Cinnamoyl-CoA reductase:
feruloyl-CoA + NADPH + H+→coniferaldehyde + coenzyme A + NADP+ (EC 1.2.1.44)
No genes
coniferaldehyde + dioxygen + a reduced [NADPH-hemoprotein reductase]→5-hydroxy-coniferaldehyde + an oxidized [NADPH-hemoprotein reductase] + H2O
No genes
Coniferyl-alcohol dehydrogenase (in reverse):
coniferaldehyde + NADPH + H+→coniferyl alcohol + NADP+ (EC 1.1.1.194; 1.1.1.195)
No genes
Caffeate O-methyltransferase:
5-hydroxy-coniferaldehyde + S-adenosyl-L-methionine→sinapaldehyde + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.68)
No genes
Cinnamyl-alcohol dehydrogenase (in reverse):
sinapaldehyde + NADPH + H+→sinapyl alcohol + NADP+ (EC 1.1.1.195)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information