MetaCyc Pathway: CMP-3-deoxy-D-manno-octulosonate biosynthesis in Escherichia coli BW25113

Reactions and Genes	Nalidixic 0.006 mg/ml
Arabinose-5-phosphate isomerase (in reverse): D-ribulose 5-phosphate→aldehydo-D-arabinose 5-phosphate (EC 5.3.1.13)
b2708 (gutQ)	+0.0
b3197 (kdsD)	-1.3
aldehydo-D-arabinose 5-phosphate→D-arabinofuranose 5-phosphate (spontaneous)
No genes
3-deoxy-8-phosphooctulonate synthase: D-arabinofuranose 5-phosphate + phosphoenolpyruvate + H2O→3-deoxy-D-manno-octulosonate 8-phosphate + phosphate (EC 2.5.1.55)
b1215 (kdsA)	N.D.
3-deoxy-manno-octulosonate-8-phosphatase: 3-deoxy-D-manno-octulosonate 8-phosphate + H2O→3-deoxy-α-D-manno-2-octulosonate + phosphate (EC 3.1.3.45)
b3198 (kdsC)	-1.7
3-deoxy-manno-octulosonate cytidylyltransferase: 3-deoxy-α-D-manno-2-octulosonate + CTP→CMP-3-deoxy-β-D-manno-octulosonate + diphosphate (EC 2.7.7.38)
b0918 (kdsB)	N.D.

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information