MetaCyc Pathway: arsenic detoxification (yeast) in Escherichia coli BW25113

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Reactions and Genes HMW_DNA_from_Pseudomonas_EB271-B4-1 46.9 ppm (C)
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arsenate[out] + Na+[out]→arsenate[in] + Na+[in]
No genes
arsenous acid[out]→arsenous acid[in]
b3927 (glpF) -1.7
arsenous acid→arsenite + H+ (spontaneous)
No genes
Arsenate reductase (glutaredoxin):
arsenate + glutathione + 2 H+ + a reduced glutaredoxin→arsenous acid + a [glutaredoxin]-glutathione disulfide + H2O (EC 1.20.4.1)
b2495 (yfgD) +0.5
b3503 (arsC) -0.1
arsenous acid + 3 glutathione→arsenic triglutathione + 3 H2O (spontaneous)
No genes
arsenite[in] + H+[out]→arsenite[out] + H+[in]
No genes
arsenic triglutathione[in] + ATP[in] + H2O[in]→arsenic triglutathione[out] + ADP[in] + H+[in] + phosphate[in] (EC 7.6.2.3)
No genes
Arsenite methyltransferase:
arsenic triglutathione + an [arsenite methyltransferase]→an arsenite-[arsenite methyltransferase] + 3 glutathione (EC 2.1.1.137)
No genes
Arsenite methyltransferase:
an arsenite-[arsenite methyltransferase] + a reduced thioredoxin + S-adenosyl-L-methionine→a methylarsenite-[arsenite methyltransferase] + S-adenosyl-L-homocysteine + an oxidized thioredoxin + H+ (EC 2.1.1.137)
No genes
Arsenite methyltransferase:
a methylarsenite-[arsenite methyltransferase] + 2 H2O→methylarsonous acid + an [arsenite methyltransferase] (EC 2.1.1.137)
No genes
Arsenite methyltransferase:
a methylarsenite-[arsenite methyltransferase] + a reduced thioredoxin + S-adenosyl-L-methionine→a dimethylarsenite-[arsenite methyltransferase] + S-adenosyl-L-homocysteine + an oxidized thioredoxin + H+ (EC 2.1.1.137)
No genes
Arsenite methyltransferase:
a dimethylarsenite-[arsenite methyltransferase] + H2O→dimethylarsinous acid + an [arsenite methyltransferase] (EC 2.1.1.137)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information