MetaCyc Pathway: L-isoleucine degradation I in Bosea sp. OAE506

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Reactions and Genes Ying_all64 rep A; time point 3
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Branched-chain-amino-acid transaminase:
L-isoleucine + 2-oxoglutarate→(3S)-3-methyl-2-oxopentanoate + L-glutamate (EC 2.6.1.42)
ABIE41_RS11405 -0.0
ABIE41_RS22510 -0.1
2-oxoisovalerate dehydrogenase (acylating):
(3S)-3-methyl-2-oxopentanoate + coenzyme A + NAD+→(2S)-2-methylbutanoyl-CoA + CO2 + NADH (EC 1.2.1.25)
No genes
(2S)-2-methylbutanoyl-CoA + an oxidized electron-transfer flavoprotein + H+→(E)-2-methylcrotonoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.5)
No genes
(E)-2-methylcrotonoyl-CoA + H2O→(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA (EC 4.2.1.150)
ABIE41_RS04195 -0.2
ABIE41_RS07775 -0.1
ABIE41_RS07780 -0.1
ABIE41_RS10405 -0.1
ABIE41_RS16295 +0.2
ABIE41_RS17285 -0.7
ABIE41_RS18700 +0.8
ABIE41_RS19240 +0.1
ABIE41_RS20600 N.D.
ABIE41_RS23310 -0.2
3-hydroxy-2-methylbutyryl-CoA dehydrogenase:
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD+→2-methylacetoacetyl-CoA + NADH + H+ (EC 1.1.1.178)
ABIE41_RS04860 -0.9
ABIE41_RS07780 -0.1
ABIE41_RS12780 -0.0
ABIE41_RS18595 -0.1
ABIE41_RS23310 -0.2
Acetyl-CoA C-acyltransferase (in reverse):
2-methylacetoacetyl-CoA + coenzyme A→acetyl-CoA + propanoyl-CoA (EC 2.3.1.16)
ABIE41_RS07785 -2.0
ABIE41_RS07970 +0.2
ABIE41_RS08710 N.D.
ABIE41_RS23315 -0.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information