MetaCyc Pathway: superpathway of L-phenylalanine biosynthesis in Pseudomonas simiae WCS417

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Reactions and Genes Urea (N)
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3-deoxy-7-phosphoheptulonate synthase:
D-erythrose 4-phosphate + phosphoenolpyruvate + H2O→3-deoxy-D-arabino-heptulosonate 7-phosphate + phosphate (EC 2.5.1.54)
PS417_08430 -1.6
PS417_08525 -0.0
PS417_10705 +0.0
3-dehydroquinate synthase:
3-deoxy-D-arabino-heptulosonate 7-phosphate→3-dehydroquinate + phosphate (EC 4.2.3.4)
PS417_01985 N.D.
3-dehydroquinate dehydratase:
3-dehydroquinate→3-dehydroshikimate + H2O (EC 4.2.1.10)
PS417_06310 N.D.
PS417_18950 +0.1
PS417_24430 +0.4
PS417_02975 +0.1
Shikimate dehydrogenase (in reverse):
3-dehydroshikimate + NADPH + H+→shikimate + NADP+ (EC 1.1.1.25)
PS417_10420 +0.1
PS417_00125 N.D.
PS417_24435 -0.2
Shikimate kinase:
shikimate + ATP→shikimate 3-phosphate + ADP + H+ (EC 2.7.1.71)
PS417_01980 N.D.
3-phosphoshikimate 1-carboxyvinyltransferase:
shikimate 3-phosphate + phosphoenolpyruvate→5-enolpyruvoyl-shikimate 3-phosphate + phosphate (EC 2.5.1.19)
PS417_08135 -0.9
PS417_12855 -4.5
Chorismate synthase:
5-enolpyruvoyl-shikimate 3-phosphate→chorismate + phosphate (EC 4.2.3.5)
PS417_19315 N.D.
Chorismate mutase:
chorismate→prephenate (EC 5.4.99.5)
PS417_08125 -3.6
PS417_01650 +0.1
Prephenate dehydratase:
prephenate + H+→3-phenyl-2-oxopropanoate + CO2 + H2O (EC 4.2.1.51)
PS417_07360 -0.2
PS417_08125 -3.6
Aspartate transaminase (in reverse):
3-phenyl-2-oxopropanoate + L-glutamate→L-phenylalanine + 2-oxoglutarate (EC 2.6.1.1; 2.6.1.27; 2.6.1.57)
PS417_08130 -0.5
PS417_08560 +0.1
PS417_09070 +0.3
PS417_09120 +0.0
PS417_11840 -0.1
PS417_12775 -0.1
PS417_12985 -0.2
PS417_13545 +0.3
PS417_14865 -0.0
PS417_15040 +0.1
PS417_15990 +0.0
PS417_18690 -1.9
PS417_19025 +0.1
PS417_19385 +0.2
PS417_19910 -0.1
PS417_21030 -0.7
PS417_21275 -0.1
PS417_23120 -0.1
PS417_23365 -0.1
PS417_27730 +0.1
PS417_28165 +0.3
PS417_04425 -0.0

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information