| Reactions and Genes | R2A with Vancomycin 0.009 mM |
|---|
| remove |
| a mature peptidoglycan (meso-DAP containing)→a mature peptidoglycan (meso-DAP containing) + GlcNAc-1,6-anhMurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala (EC 4.2.2.f) |
| No genes |
| GlcNAc-1,6-anhMurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala[out] + H+[out]→GlcNAc-1,6-anhMurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala[in] + H+[in] |
| No genes |
N-acetylmuramoyl-L-alanine amidase:
GlcNAc-1,6-anhMurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala + H2O→N-acetyl-β-D-glucosamine-1,6-anhydro-N-acetyl-β-D-muramate + L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanine (EC 3.5.1.28) |
| Atu1340 | N.D. |
| Atu2113 | -1.7 |
Beta-N-acetylhexosaminidase:
N-acetyl-β-D-glucosamine-1,6-anhydro-N-acetyl-β-D-muramate + H2O→1,6-anhydro-N-acetyl-β-D-muramate + N-acetyl-D-glucosamine (EC 3.2.1.52) |
| Atu1709 | -2.2 |
| Atu2596 | -0.0 |
Muramoyltetrapeptide carboxypeptidase:
L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanine + H2O→L-alanyl-γ-D-glutamyl-meso-diaminopimelate + D-alanine (EC 3.4.17.13) |
| No genes |
| 1,6-anhydro-N-acetyl-β-D-muramate + ATP + H2O→N-acetyl-D-muramate 6-phosphate + ADP + H+ (EC 2.7.1.170) |
| No genes |
| N-acetyl-D-muramate 6-phosphate + H2O→N-acetyl-D-glucosamine 6-phosphate + (R)-lactate (EC 4.2.1.126) |
| No genes |
N-acetylglucosamine-6-phosphate deacetylase:
N-acetyl-D-glucosamine 6-phosphate + H2O→D-glucosamine 6-phosphate + acetate (EC 3.5.1.25) |
| Atu2608 | -1.1 |
Phosphoglucosamine mutase:
D-glucosamine 6-phosphate→α-D-glucosamine 1-phosphate (EC 5.4.2.10) |
| Atu3709 | N.D. |
Glucosamine-1-phosphate N-acetyltransferase:
α-D-glucosamine 1-phosphate + acetyl-CoA→N-acetyl-α-D-glucosamine 1-phosphate + coenzyme A + H+ (EC 2.3.1.157) |
| Atu1787 | N.D. |
UDP-N-acetylglucosamine diphosphorylase:
N-acetyl-α-D-glucosamine 1-phosphate + H+ + UTP→UDP-N-acetyl-α-D-glucosamine + diphosphate (EC 2.7.7.23) |
| Atu1787 | N.D. |
UDP-N-acetylglucosamine 1-carboxyvinyltransferase:
UDP-N-acetyl-α-D-glucosamine + phosphoenolpyruvate→UDP-N-acetyl-α-D-glucosamine-enolpyruvate + phosphate (EC 2.5.1.7) |
| Atu0539 | N.D. |
| UDP-N-acetyl-α-D-glucosamine-enolpyruvate + NADPH + H+→UDP-N-acetyl-α-D-muramate + NADP+ (EC 1.3.1.98) |
| Atu2092 | N.D. |
| L-alanyl-γ-D-glutamyl-meso-diaminopimelate + UDP-N-acetyl-α-D-muramate + ATP→UDP-MurNAc-L-Ala-γ-D-Glu-meso-DAP + ADP + H+ + phosphate (EC 6.3.2.45) |
| No genes |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information