MetaCyc Pathway: peptidoglycan biosynthesis I (meso-diaminopimelate containing) in Agrobacterium fabrum C58

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Reactions and Genes R2A with Vancomycin 0.009 mM
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D-alanine--D-alanine ligase:
2 D-alanine + ATP→D-alanyl-D-alanine + ADP + H+ + phosphate (EC 6.3.2.4)
Atu2089 N.D.
Glutamate racemase:
L-glutamate→D-glutamate (EC 5.1.1.3)
Atu1867 -1.2
UDP-N-acetylglucosamine 1-carboxyvinyltransferase:
UDP-N-acetyl-α-D-glucosamine + phosphoenolpyruvate→UDP-N-acetyl-α-D-glucosamine-enolpyruvate + phosphate (EC 2.5.1.7)
Atu0539 N.D.
UDP-N-acetyl-α-D-glucosamine-enolpyruvate + NADPH + H+→UDP-N-acetyl-α-D-muramate + NADP+ (EC 1.3.1.98)
Atu2092 N.D.
UDP-N-acetylmuramate--L-alanine ligase:
UDP-N-acetyl-α-D-muramate + L-alanine + ATP→UDP-N-acetyl-α-D-muramoyl-L-alanine + ADP + H+ + phosphate (EC 6.3.2.8)
Atu2093 N.D.
UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase:
UDP-N-acetyl-α-D-muramoyl-L-alanine + D-glutamate + ATP→UDP-N-acetyl-α-D-muramoyl-L-alanyl-D-glutamate + ADP + H+ + phosphate (EC 6.3.2.9)
Atu2096 N.D.
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase:
UDP-N-acetyl-α-D-muramoyl-L-alanyl-D-glutamate + meso-diaminopimelate + ATP→UDP-MurNAc-L-Ala-γ-D-Glu-meso-DAP + ADP + H+ + phosphate (EC 6.3.2.13)
Atu2099 N.D.
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase:
D-alanyl-D-alanine + UDP-MurNAc-L-Ala-γ-D-Glu-meso-DAP + ATP→UDP-MurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala-D-Ala + ADP + H+ + phosphate (EC 6.3.2.10)
Atu2098 N.D.
Phospho-N-acetylmuramoyl-pentapeptide-transferase:
UDP-MurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala-D-Ala + di-trans,octa-cis-undecaprenyl phosphate→Und-PP-MurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala-D-Ala + UMP (EC 2.7.8.13)
Atu2097 N.D.
acetylglucosaminyltransferase:
Und-PP-MurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala-D-Ala + UDP-N-acetyl-α-D-glucosamine→Und-PP-[β-D-GlcNAc-(1→4)]-MurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala-D-Ala + H+ + UDP (EC 2.4.1.227)
Atu2094 N.D.
Und-PP-[β-D-GlcNAc-(1→4)]-MurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala-D-Ala[in] + H+[out]→Und-PP-[β-D-GlcNAc-(1→4)]-MurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala-D-Ala[out] + H+[in]
No genes
Peptidoglycan glycosyltransferase:
Und-PP-[β-D-GlcNAc-(1→4)]-MurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala-D-Ala + a nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine) pentapeptide→a nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine) pentapeptide + di-trans,octa-cis-undecaprenyl diphosphate (EC 2.4.1.129)
Atu0103 -3.0
Atu0931 +3.6
Atu1067 -0.5
Atu1341 N.D.
Atu2100 N.D.
Atu3694 -0.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information