MetaCyc Pathway: pyruvate fermentation to propanoate I in Escherichia coli BW25113
| Reactions and Genes | Ying_AminoAcid20 rep C; time point 3 |
|---|---|
| remove | |
| Methylmalonyl-CoA carboxytransferase: (S)-methylmalonyl-CoA + pyruvate→oxaloacetate + propanoyl-CoA (EC 2.1.3.1) | |
| No genes | |
| Malate dehydrogenase (in reverse): oxaloacetate + NADH + H+→(S)-malate + NAD+ (EC 1.1.1.37; 1.1.1.38) | |
| b0801 (ybiC) | +0.2 |
| b1479 (sfcA) | +0.4 |
| b3236 (mdh) | -6.5 |
| Fumarate hydratase: (S)-malate→fumarate + H2O (EC 4.2.1.2) | |
| b1611 (fumC) | -1.6 |
| b1612 (fumA) | -0.0 |
| b1675 (ydhZ) | -0.3 |
| b2929 (yggD) | +0.1 |
| b4122 (fumB) | -0.2 |
| Succinate dehydrogenase (ubiquinone): fumarate[in] + a menaquinol→succinate[in] + a menaquinone (EC 1.3.5.1) | |
| b4151 (frdD) | +0.0 |
| b4152 (frdC) | +0.3 |
| b4153 (frdB) | +0.1 |
| b4154 (frdA) | +0.1 |
| propanoyl-CoA + succinate→succinyl-CoA + propanoate (EC 2.8.3.27) | |
| b2920 (ygfH) | +0.1 |
| Methylmalonyl-CoA mutase (in reverse): succinyl-CoA→(R)-methylmalonyl-CoA (EC 5.4.99.2) | |
| b2917 (yliK) | +0.1 |
| Methylmalonyl-CoA epimerase: (R)-methylmalonyl-CoA→(S)-methylmalonyl-CoA (EC 5.1.99.1) | |
| No genes | |
Links:
- Pathway details at MetaCyc
- Fitness data for 14 genes
- All MetaCyc pathways for Escherichia coli BW25113
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information