MetaCyc Pathway: superpathway of anaerobic energy metabolism (invertebrates) in Escherichia coli BW25113

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Reactions and Genes Ying_AminoAcid20 rep A; time point 3
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Phosphoenolpyruvate carboxykinase (GTP) (in reverse):
phosphoenolpyruvate + CO2 + GDP→oxaloacetate + GTP (EC 4.1.1.32)
No genes
Pyruvate kinase (in reverse):
phosphoenolpyruvate + ADP + H+→pyruvate + ATP (EC 2.7.1.40)
b1676 (pykF) +0.2
b1854 (pykA) -0.2
Phosphoenolpyruvate carboxykinase (GTP) (in reverse):
phosphoenolpyruvate + CO2 + IDP→oxaloacetate + ITP (EC 4.1.1.32)
No genes
Alanine transaminase (in reverse):
pyruvate + L-glutamate→2-oxoglutarate + L-alanine (EC 2.6.1.2)
b2290 (yfbQ) -0.2
b2379 (yfdZ) -0.1
Malate dehydrogenase (in reverse):
oxaloacetate + NADH + H+→(S)-malate + NAD+ (EC 1.1.1.37; 1.1.1.38)
b0801 (ybiC) +0.2
b1479 (sfcA) +0.1
b3236 (mdh) -7.0
Malate dehydrogenase (oxaloacetate-decarboxylating):
(S)-malate + NAD+→pyruvate + CO2 + NADH (EC 1.1.1.38)
b1479 (sfcA) +0.1
Alanine racemase:
L-alanine→D-alanine (EC 5.1.1.1; 5.1.1.10)
b1190 (dadX) -1.7
b1622 (malY) +0.1
b3008 (metC) -0.1
b4053 (alr) +0.0
Aspartate transaminase:
2-oxoglutarate + L-aspartate→L-glutamate + oxaloacetate (EC 2.6.1.1)
b0928 (aspC) -4.9
b4340 (yjiR) -0.0
Fumarate hydratase:
(S)-malate→fumarate + H2O (EC 4.2.1.2)
b1611 (fumC) -1.5
b1612 (fumA) +0.0
b1675 (ydhZ) -0.5
b2929 (yggD) +0.0
b4122 (fumB) -0.2
pyruvate + coenzyme A + NAD+→CO2 + acetyl-CoA + NADH (EC 1.2.1.104)
b0114 (aceE) -2.5
b0115 (aceF) N.D.
b0116 (lpd) N.D.
Succinate dehydrogenase (ubiquinone) (in reverse):
fumarate[in] + a rhodoquinol→succinate[in] + a rhodoquinone (EC 1.3.5.1)
No genes
acetyl-CoA + succinate→acetate + succinyl-CoA (EC 2.8.3.18)
No genes
succinate + propanoyl-CoA→succinyl-CoA + propanoate (EC 2.8.3.27)
b2920 (ygfH) +0.2
Methylmalonyl-CoA mutase (in reverse):
succinyl-CoA→(R)-methylmalonyl-CoA (EC 5.4.99.2)
b2917 (yliK) +0.1
Succinate--CoA ligase (ADP-forming) (in reverse):
succinyl-CoA + ADP + phosphate→succinate + ATP + coenzyme A (EC 6.2.1.5)
b0728 (sucC) -8.3
b0729 (sucD) -7.8
Methylmalonyl-CoA epimerase:
(R)-methylmalonyl-CoA→(S)-methylmalonyl-CoA (EC 5.1.99.1)
No genes
Propionyl-CoA carboxylase (in reverse):
(S)-methylmalonyl-CoA + ADP + H+ + phosphate→propanoyl-CoA + ATP + hydrogen carbonate (EC 6.4.1.3)
b0185 (accA) N.D.
b2316 (accD) N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information