MetaCyc Pathway: (aminomethyl)phosphonate degradation in Escherichia coli BW25113

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Reactions and Genes Ying_Nucleobase14 rep B; time point 2
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(aminomethyl)phosphonate + acetyl-CoA→(acetamidomethyl)phosphonate + coenzyme A (EC 2.3.1.280)
b4093 (phnO) +0.0
(acetamidomethyl)phosphonate + ATP→α-D-ribose 1-(acetamidomethylphosphonate) 5-triphosphate + adenine (EC 2.7.8.37)
b4099 (phnI) -0.2
α-D-ribose 1-(acetamidomethylphosphonate) 5-triphosphate + H2O→α-D-ribose-1-(2-N-acetamidomethylphosphonate) 5-phosphate + diphosphate + H+ (EC 3.6.1.63)
b4095 (phnM) -0.3
α-D-ribose-1-(2-N-acetamidomethylphosphonate) 5-phosphate + a reduced two electron carrier + S-adenosyl-L-methionine→5-phospho-α-D-ribose 1,2-cyclic phosphate + an oxidized electron carrier + 5'-deoxyadenosine + N-methylacetamide + L-methionine + H+ (EC 4.7.1.1)
b4098 (phnJ) -0.7
5-phospho-α-D-ribose 1,2-cyclic phosphate + H2O→α-D-ribose 1,5-bisphosphate + H+ (EC 3.1.4.55)
b4092 (phnP) +0.0
Ribose 1,5-bisphosphate phosphokinase:
α-D-ribose 1,5-bisphosphate + ATP→5-phospho-α-D-ribose 1-diphosphate + ADP (EC 2.7.4.23)
b4094 (phnN) +0.1
Adenine phosphoribosyltransferase (in reverse):
5-phospho-α-D-ribose 1-diphosphate + adenine→diphosphate + AMP (EC 2.4.2.7)
b0469 (apt) -1.1
Inorganic diphosphatase:
diphosphate + H2O→2 phosphate + H+ (EC 3.6.1.1)
b0383 (phoA) -0.0
b4226 (ppa) N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information