MetaCyc Pathway: superpathway of glucose and xylose degradation in Escherichia coli BW25113

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Reactions and Genes Ying_Nucleobase14 rep B; time point 2
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Glucose-6-phosphate dehydrogenase:
D-glucopyranose 6-phosphate + NADP+→6-phospho D-glucono-1,5-lactone + NADPH + H+ (EC 1.1.1.49)
b1852 (zwf) N.D.
Xylose isomerase:
α-D-xylopyranose→α-D-xylulofuranose (EC 5.3.1.5)
b3565 (xylA) +0.3
6-phosphogluconolactonase:
6-phospho D-glucono-1,5-lactone + H2O→D-gluconate 6-phosphate + H+ (EC 3.1.1.31)
b0767 (ybhE) -1.5
Xylulokinase:
D-xylulose + ATP→D-xylulose 5-phosphate + ADP + H+ (EC 2.7.1.17)
b3564 (xylB) +0.2
Phosphogluconate dehydrogenase (decarboxylating):
D-gluconate 6-phosphate + NADP+→D-ribulose 5-phosphate + CO2 + NADPH (EC 1.1.1.44)
b2029 (gnd) -0.6
Ribose-5-phosphate isomerase (in reverse):
D-ribulose 5-phosphate→D-ribose 5-phosphate (EC 5.3.1.6)
b2914 (rpiA) N.D.
b4090 (rpiB) +0.3
Ribulose-phosphate 3-epimerase:
D-ribulose 5-phosphate→D-xylulose 5-phosphate (EC 5.1.3.1)
b3386 (rpe) -1.5
b4301 (sgcE) +0.0
Transketolase (in reverse):
D-ribose 5-phosphate + D-xylulose 5-phosphate→D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (EC 2.2.1.1)
b2465 (tktB) +0.3
b2935 (tktA) +0.0
Transaldolase:
D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate→D-erythrose 4-phosphate + β-D-fructofuranose 6-phosphate (EC 2.2.1.2)
b0008 (talB) -0.3
b0825 (mipB) +0.1
b2464 (talA) +0.1
b3946 (fsaB) -0.1
Transketolase:
D-erythrose 4-phosphate + D-xylulose 5-phosphate→β-D-fructofuranose 6-phosphate + D-glyceraldehyde 3-phosphate (EC 2.2.1.1)
b2465 (tktB) +0.3
b2935 (tktA) +0.0
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating):
D-glyceraldehyde 3-phosphate + NAD+ + phosphate→3-phospho-D-glyceroyl phosphate + NADH + H+ (EC 1.2.1.12)
b1779 (gapA) N.D.
Phosphoglycerate kinase (in reverse):
3-phospho-D-glyceroyl phosphate + ADP→3-phospho-D-glycerate + ATP (EC 2.7.2.3)
b2926 (pgk) N.D.
3-phospho-D-glycerate→2-phospho-D-glycerate (EC 5.4.2.12)
b0755 (gpmA) -1.0
b3612 (gpmI) +0.1
b4395 (ytjC) -1.4
Phosphopyruvate hydratase:
2-phospho-D-glycerate→phosphoenolpyruvate + H2O (EC 4.2.1.11)
b2779 (eno) N.D.
Pyruvate kinase (in reverse):
phosphoenolpyruvate + ADP + H+→pyruvate + ATP (EC 2.7.1.40)
b1676 (pykF) -2.0
b1854 (pykA) -0.2
D-lactate dehydrogenase (in reverse):
pyruvate + NADH + H+→(R)-lactate + NAD+ (EC 1.1.1.28)
b1380 (ldhA) +0.4
b2133 (dld) +0.0
L-lactate dehydrogenase (in reverse):
pyruvate + NADH + H+→(S)-lactate + NAD+ (EC 1.1.1.27)
b0306 (ykgE) +0.0
b0307 (ykgF) +0.0

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information