MetaCyc Pathway: dTDP-β-L-rhamnose biosynthesis in Escherichia coli BW25113

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Reactions and Genes M9 Aerobic 5'-Deoxy-5-fluorocytidine 500 uM
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Phosphoglucomutase (in reverse):
D-glucopyranose 6-phosphate→α-D-glucopyranose 1-phosphate (EC 5.4.2.2)
b0688 (pgm) +0.4
b3176 (glmM) N.D.
Glucose-1-phosphate thymidylyltransferase:
α-D-glucopyranose 1-phosphate + H+ + dTTP→dTDP-α-D-glucose + diphosphate (EC 2.7.7.24)
b0363 (yaiP) +0.1
b2039 (rfbA) +0.3
b3789 (rffH) +0.1
dTDP-glucose 4,6-dehydratase:
dTDP-α-D-glucose→dTDP-4-dehydro-6-deoxy-α-D-glucopyranose + H2O (EC 4.2.1.46)
b2041 (rfbB) +0.2
b3788 (rffG) +0.0
dTDP-4-dehydrorhamnose 3,5-epimerase:
dTDP-4-dehydro-6-deoxy-α-D-glucopyranose→dTDP-4-dehydro-β-L-rhamnose (EC 5.1.3.13)
b2038 (rfbC) -1.6
dTDP-4-dehydrorhamnose reductase (in reverse):
dTDP-4-dehydro-β-L-rhamnose + NADPH + H+→dTDP-β-L-rhamnose + NADP+ (EC 1.1.1.133)
b2040 (rfbD) -1.0

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information