MetaCyc Pathway: purine nucleotides degradation II (aerobic) in Escherichia coli BW25113

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Reactions and Genes M9 Aerobic 5'-Deoxy-5-fluorocytidine 500 uM
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5'-nucleotidase:
AMP + H2O→adenosine + phosphate (EC 3.1.3.5)
b0383 (phoA) -0.2
b0480 (ushA) +0.0
b2291 (yfbR) -0.1
b2744 (surE) -0.2
b4055 (aphA) -0.2
b4374 (yjjG) -4.5
IMP dehydrogenase:
IMP + NAD+ + H2O→XMP + NADH + H+ (EC 1.1.1.205)
b2508 (guaB) N.D.
5'-nucleotidase:
GMP + H2O→guanosine + phosphate (EC 3.1.3.5)
b0480 (ushA) +0.0
b2291 (yfbR) -0.1
b2744 (surE) -0.2
b3399 (yrfG) +0.0
b4055 (aphA) -0.2
b4374 (yjjG) -4.5
Adenosine deaminase:
adenosine + H+ + H2O→inosine + ammonium (EC 3.5.4.4)
b1623 (add) -0.0
b2593 (yfiH) +0.0
Purine-nucleoside phosphorylase:
guanosine + phosphate→guanine + α-D-ribose-1-phosphate (EC 2.4.2.1; 2.4.2.15)
b0391 (yaiE) -0.3
b2407 (xapA) -0.1
b4384 (deoD) -0.1
5'-nucleotidase:
XMP + H2O→xanthosine + phosphate (EC 3.1.3.5)
b0480 (ushA) +0.0
b2291 (yfbR) -0.1
b2744 (surE) -0.2
b4055 (aphA) -0.2
b4374 (yjjG) -4.5
Guanine deaminase:
guanine + H+ + H2O→xanthine + ammonium (EC 3.5.4.3)
b2883 (guaD) +0.3
Purine-nucleoside phosphorylase:
inosine + phosphate→hypoxanthine + α-D-ribose-1-phosphate (EC 2.4.2.1)
b0391 (yaiE) -0.3
b2407 (xapA) -0.1
b2593 (yfiH) +0.0
b4384 (deoD) -0.1
Purine-nucleoside phosphorylase:
xanthosine + phosphate→xanthine + α-D-ribose-1-phosphate (EC 2.4.2.1)
b0391 (yaiE) -0.3
b2407 (xapA) -0.1
b4384 (deoD) -0.1
Xanthine dehydrogenase:
hypoxanthine + NAD+ + H2O→xanthine + NADH + H+ (EC 1.17.1.4)
b0284 (yagR) +0.2
b0285 (yagS) +0.1
b2866 (xdhA) +0.0
b2867 (xdhB) +0.1
b2868 (xdhC) -0.2
Xanthine dehydrogenase:
xanthine + NAD+ + H2O→urate + NADH + H+ (EC 1.17.1.4)
b0284 (yagR) +0.2
b0285 (yagS) +0.1
b2866 (xdhA) +0.0
b2867 (xdhB) +0.1
b2868 (xdhC) -0.2

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information