MetaCyc Pathway: superpathway of purines degradation in plants in Escherichia coli BW25113

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Reactions and Genes M9 Anaerobic Capecitabine 500 uM
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Adenosine-phosphate deaminase:
AMP + H+ + H2O→IMP + ammonium (EC 3.5.4.17; 3.5.4.6)
No genes
5'-nucleotidase:
GMP + H2O→guanosine + phosphate (EC 3.1.3.5)
b0480 (ushA) -0.0
b2291 (yfbR) +0.3
b2744 (surE) -0.3
b3399 (yrfG) +0.0
b4055 (aphA) -0.1
b4374 (yjjG) -1.4
Guanosine deaminase:
guanosine + H+ + H2O→xanthosine + ammonium (EC 3.5.4.15)
No genes
IMP dehydrogenase:
IMP + NAD+ + H2O→XMP + NADH + H+ (EC 1.1.1.205)
b2508 (guaB) N.D.
5'-nucleotidase:
IMP + H2O→inosine + phosphate (EC 3.1.3.5; 3.1.3.99)
b0383 (phoA) +0.1
b0480 (ushA) -0.0
b2291 (yfbR) +0.3
b2744 (surE) -0.3
b3399 (yrfG) +0.0
b4055 (aphA) -0.1
b4374 (yjjG) -1.4
Purine nucleosidase:
guanosine + H2O→guanine + D-ribofuranose (EC 3.2.2.1)
b0030 (rihC) -0.0
b0651 (rihA) -0.1
b2162 (rihB) +0.1
Guanine deaminase:
guanine + H+ + H2O→xanthine + ammonium (EC 3.5.4.3)
b2883 (guaD) +0.0
Inosine nucleosidase:
inosine + H2O→hypoxanthine + D-ribofuranose (EC 3.2.2.2)
b0030 (rihC) -0.0
b0651 (rihA) -0.1
b2162 (rihB) +0.1
5'-nucleotidase:
XMP + H2O→xanthosine + phosphate (EC 3.1.3.5)
b0480 (ushA) -0.0
b2291 (yfbR) +0.3
b2744 (surE) -0.3
b4055 (aphA) -0.1
b4374 (yjjG) -1.4
Xanthine dehydrogenase:
hypoxanthine + NAD+ + H2O→xanthine + NADH + H+ (EC 1.17.1.4)
b0284 (yagR) +0.0
b0285 (yagS) -0.1
b2866 (xdhA) +0.0
b2867 (xdhB) -0.1
b2868 (xdhC) +0.1
Purine nucleosidase:
xanthosine + H2O→xanthine + D-ribofuranose (EC 3.2.2.1)
b0030 (rihC) -0.0
b0651 (rihA) -0.1
b2162 (rihB) +0.1
Xanthine dehydrogenase:
xanthine + NAD+ + H2O→urate + NADH + H+ (EC 1.17.1.4)
b0284 (yagR) +0.0
b0285 (yagS) -0.1
b2866 (xdhA) +0.0
b2867 (xdhB) -0.1
b2868 (xdhC) +0.1
Urate oxidase:
urate + dioxygen + H2O→(S)-5-hydroxyisourate + hydrogen peroxide (EC 1.7.3.3)
No genes
Hydroxyisourate hydrolase:
(S)-5-hydroxyisourate + H2O→(S)-2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline + H+ (EC 3.5.2.17)
b1970 (yedX) -0.0
(S)-2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline + H+→(S)-(+)-allantoin + CO2 (EC 4.1.1.97)
No genes
Allantoinase:
(S)-(+)-allantoin + H2O→allantoate + H+ (EC 3.5.2.5)
b0512 (allB) +0.1
Allantoicase:
allantoate + H2O→(S)-ureidoglycolate + urea (EC 3.5.3.4)
No genes
Ureidoglycolate lyase:
(S)-ureidoglycolate→glyoxylate + urea (EC 4.3.2.3)
b0505 (allA) -0.0

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information