MetaCyc Pathway: formaldehyde oxidation VII (THF pathway) in Pseudomonas putida KT2440

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Reactions and Genes Time6-nophage
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formaldehyde + a tetrahydrofolate→a 5,10-methylenetetrahydrofolate + H2O (spontaneous)
No genes
Methylenetetrahydrofolate dehydrogenase (NADP(+)):
a 5,10-methylenetetrahydrofolate + NADP+→a 5,10-methenyltetrahydrofolate + NADPH (EC 1.5.1.5)
PP_1945 +0.0
PP_2265 N.D.
Methenyltetrahydrofolate cyclohydrolase:
a 5,10-methenyltetrahydrofolate + H2O→an N10-formyltetrahydrofolate + H+ (EC 3.5.4.9)
PP_1945 +0.0
PP_2265 N.D.
Formyltetrahydrofolate deformylase:
an N10-formyltetrahydrofolate + H2O→formate + H+ + a tetrahydrofolate (EC 3.5.1.10)
PP_0327 +0.2
PP_1367 -3.7
PP_1943 -0.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information