MetaCyc Pathway: superpathway of L-tyrosine biosynthesis in Pseudomonas sp. RS175

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Reactions and Genes D-Glucosamine Hydrochloride (C) 10 mM
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3-deoxy-7-phosphoheptulonate synthase:
D-erythrose 4-phosphate + phosphoenolpyruvate + H2O→3-deoxy-D-arabino-heptulosonate 7-phosphate + phosphate (EC 2.5.1.54)
PFR28_00962 -0.3
PFR28_00978 +0.1
PFR28_01407 -0.1
3-dehydroquinate synthase:
3-deoxy-D-arabino-heptulosonate 7-phosphate→3-dehydroquinate + phosphate (EC 4.2.3.4)
PFR28_01544 -0.1
PFR28_05013 N.D.
3-dehydroquinate dehydratase:
3-dehydroquinate→3-dehydroshikimate + H2O (EC 4.2.1.10)
PFR28_00416 N.D.
PFR28_03810 -0.0
PFR28_05222 N.D.
Shikimate dehydrogenase (in reverse):
3-dehydroshikimate + NADPH + H+→shikimate + NADP+ (EC 1.1.1.25)
PFR28_01211 +2.6
PFR28_03811 +0.2
PFR28_04655 N.D.
Shikimate kinase:
shikimate + ATP→shikimate 3-phosphate + ADP + H+ (EC 2.7.1.71)
PFR28_05012 N.D.
3-phosphoshikimate 1-carboxyvinyltransferase:
shikimate 3-phosphate + phosphoenolpyruvate→5-enolpyruvoyl-shikimate 3-phosphate + phosphate (EC 2.5.1.19)
PFR28_00909 +0.2
Chorismate synthase:
5-enolpyruvoyl-shikimate 3-phosphate→chorismate + phosphate (EC 4.2.3.5)
PFR28_03126 N.D.
Chorismate mutase:
chorismate→prephenate (EC 5.4.99.5)
PFR28_00907 N.D.
PFR28_04948 +0.2
Prephenate dehydrogenase:
prephenate + NAD+→3-(4-hydroxyphenyl)pyruvate + CO2 + NADH (EC 1.3.1.12)
PFR28_00909 +0.2
Aspartate transaminase (in reverse):
3-(4-hydroxyphenyl)pyruvate + L-glutamate→L-tyrosine + 2-oxoglutarate (EC 2.6.1.1; 2.6.1.27; 2.6.1.5; 2.6.1.57)
PFR28_00188 -1.7
PFR28_00302 -0.0
PFR28_00800 +0.4
PFR28_00908 -0.1
PFR28_00984 +0.0
PFR28_01312 -1.0
PFR28_01605 -0.2
PFR28_01790 -0.1
PFR28_02468 +0.2
PFR28_02838 -1.3
PFR28_02973 -0.0
PFR28_03061 +0.0
PFR28_03135 +0.0
PFR28_04404 +0.1
PFR28_04508 -0.0

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information