MetaCyc Pathway: superpathway of sulfate assimilation and cysteine biosynthesis in Pseudomonas sp. RS175

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Reactions and Genes L-Hydroxyproline (C) 10 mM
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Phosphoglycerate dehydrogenase:
3-phospho-D-glycerate + NAD+→3-phosphooxypyruvate + NADH + H+ (EC 1.1.1.95)
PFR28_00714 -0.1
PFR28_01519 -0.3
PFR28_02144 -0.1
PFR28_02378 -0.1
PFR28_03622 N.D.
PFR28_04842 -2.5
Sulfate adenylyltransferase:
sulfate + ATP + H+→adenosine 5'-phosphosulfate + diphosphate (EC 2.7.7.4)
PFR28_00193 -2.9
PFR28_00194 -2.3
Adenylyl-sulfate kinase:
adenosine 5'-phosphosulfate + ATP→3'-phosphoadenylyl-sulfate + ADP + H+ (EC 2.7.1.25)
PFR28_00194 -2.3
PFR28_05082 +0.1
Phosphoserine transaminase (in reverse):
3-phosphooxypyruvate + L-glutamate→O-phospho-L-serine + 2-oxoglutarate (EC 2.6.1.52)
PFR28_00906 N.D.
Phosphoadenylyl-sulfate reductase (thioredoxin) (in reverse):
3'-phosphoadenylyl-sulfate + a reduced thioredoxin→sulfite + adenosine 3',5'-bisphosphate + an oxidized thioredoxin + 2 H+ (EC 1.8.4.8)
PFR28_02935 N.D.
Phosphoserine phosphatase:
O-phospho-L-serine + H2O→L-serine + phosphate (EC 3.1.3.3)
PFR28_02934 +1.2
PFR28_03165 -0.1
PFR28_04279 -0.1
PFR28_04832 -1.4
PFR28_05105 -2.9
Serine O-acetyltransferase:
L-serine + acetyl-CoA→O-acetyl-L-serine + coenzyme A (EC 2.3.1.30)
PFR28_00284 -0.3
Sulfite reductase (NADPH) (in reverse):
sulfite + 3 NADPH + 5 H+→hydrogen sulfide + 3 NADP+ + 3 H2O (EC 1.8.1.2)
PFR28_00109 -0.1
PFR28_01366 -2.9
Cysteine synthase:
O-acetyl-L-serine + hydrogen sulfide→L-cysteine + acetate + H+ (EC 2.5.1.47)
PFR28_00527 +0.2
PFR28_00734 +0.1
PFR28_03225 N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information