MetaCyc Pathway: TCA cycle VIII (Chlamydia) in Pseudomonas sp. RS175

Reactions and Genes	L-Isoleucine (C) 10 mM
	remove
2-oxoglutarate + coenzyme A + NAD⁺→succinyl-CoA + CO₂ + NADH (EC 1.2.1.105)
No genes
Succinate--CoA ligase (ADP-forming) (in reverse): succinyl-CoA + ADP + phosphate→succinate + ATP + coenzyme A (EC 6.2.1.5)
PFR28_03092	N.D.
PFR28_03093	N.D.
Succinate dehydrogenase (ubiquinone): succinate_[in] + an electron-transfer quinone→fumarate_[in] + an electron-transfer quinol (EC 1.3.5.1)
PFR28_03097	N.D.
PFR28_03098	N.D.
PFR28_03099	N.D.
PFR28_03100	N.D.
Fumarate hydratase (in reverse): fumarate + H₂O→(S)-malate (EC 4.2.1.2)
PFR28_00165	-0.1
PFR28_00889	+0.2
PFR28_03458	N.D.
Malate dehydrogenase: (S)-malate + NAD⁺→oxaloacetate + NADH + H⁺ (EC 1.1.1.37; 1.1.1.38)
No genes
Aspartate transaminase (in reverse): oxaloacetate + L-glutamate→2-oxoglutarate + L-aspartate (EC 2.6.1.1)
PFR28_00302	-0.0
PFR28_00800	+0.1
PFR28_00984	-0.0
PFR28_01312	-0.9
PFR28_01605	-0.1
PFR28_01790	+0.0
PFR28_02468	+0.0
PFR28_02973	-1.8
PFR28_03061	-0.2
PFR28_03135	+0.0
PFR28_04404	+0.1
PFR28_04508	-0.0

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Pathway details at MetaCyc
Fitness data for 21 genes
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All MetaCyc pathways for Pseudomonas sp. RS175

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information