MetaCyc Pathway: trans-4-hydroxy-L-proline degradation I in Pseudomonas sp. RS175

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Reactions and Genes L-Valine (C) 10 mM
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trans-4-hydroxy-L-proline[in] + an electron-transfer quinone→(3R,5S)-3-hydroxy-1-pyrroline-5-carboxylate[in] + an electron-transfer quinol + H+[in] (EC 1.5.5.3)
No genes
(3R,5S)-3-hydroxy-1-pyrroline-5-carboxylate + H+ + H2O→L-4-hydroxyglutamate semialdehyde (spontaneous)
No genes
L-4-hydroxyglutamate semialdehyde + NAD+ + H2O→erythro-4-hydroxy-L-glutamate + NADH + 2 H+
No genes
4-hydroxyglutamate transaminase:
erythro-4-hydroxy-L-glutamate + 2-oxoglutarate→(4R)-4-hydroxy-2-oxoglutarate + L-glutamate (EC 2.6.1.23)
PFR28_00302 -0.0
PFR28_00800 -0.1
PFR28_00984 -0.1
PFR28_01312 -0.5
PFR28_01605 +0.2
PFR28_01790 +0.2
PFR28_02468 -0.0
PFR28_02973 -2.0
PFR28_03061 -0.1
PFR28_03135 -0.4
PFR28_04404 +0.2
PFR28_04508 +0.0
4-hydroxy-2-oxoglutarate aldolase:
(4R)-4-hydroxy-2-oxoglutarate→glyoxylate + pyruvate (EC 4.1.3.16)
PFR28_00575 N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information