MetaCyc Pathway: ureide biosynthesis in Escherichia coli BW25113
| Reactions and Genes | 2,4-Dinitrophenol 2 mM |
|---|---|
| remove | |
| IMP dehydrogenase: IMP + NAD+ + H2O→XMP + NADH + H+ (EC 1.1.1.205) | |
| b2508 (guaB) | N.D. |
| 5'-nucleotidase: XMP + H2O→xanthosine + phosphate (EC 3.1.3.5) | |
| b0480 (ushA) | -0.1 |
| b2291 (yfbR) | -0.0 |
| b2744 (surE) | +0.2 |
| b4055 (aphA) | +0.2 |
| b4374 (yjjG) | +0.2 |
| Purine-nucleoside phosphorylase: xanthosine + phosphate→xanthine + α-D-ribose-1-phosphate (EC 2.4.2.1) | |
| b0391 (yaiE) | -0.0 |
| b2407 (xapA) | +0.2 |
| b4384 (deoD) | -1.4 |
| Xanthine dehydrogenase: xanthine + NAD+ + H2O→urate + NADH + H+ (EC 1.17.1.4) | |
| b0284 (yagR) | -0.1 |
| b0285 (yagS) | -0.2 |
| b2866 (xdhA) | -0.0 |
| b2867 (xdhB) | +0.2 |
| b2868 (xdhC) | +0.1 |
| Urate oxidase: urate + dioxygen + H2O→(S)-5-hydroxyisourate + hydrogen peroxide (EC 1.7.3.3) | |
| No genes | |
| Hydroxyisourate hydrolase: (S)-5-hydroxyisourate + H2O→(S)-2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline + H+ (EC 3.5.2.17) | |
| b1970 (yedX) | -0.1 |
| (S)-2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline + H+→(S)-(+)-allantoin + CO2 (EC 4.1.1.97) | |
| No genes | |
Links:
- Pathway details at MetaCyc
- Fitness data for 15 genes
- All MetaCyc pathways for Escherichia coli BW25113
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information