MetaCyc Pathway: NAD de novo biosynthesis I in Variovorax sp. OAS795

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Reactions and Genes Plant=Brachypodium_distachyon; PlantTreatment=None; Sample=soil; GrowthSubstrate=quartz_sand; Collection=outgrowth_R2A_with_Tween_and_Cycloheximide; Time=21_days
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L-aspartate oxidase:
L-aspartate + dioxygen→2-iminosuccinate + hydrogen peroxide + H+ (EC 1.4.3.16)
ABID97_RS07440 +0.0
Quinolinate synthase:
2-iminosuccinate + glycerone phosphate→quinolinate + phosphate + 2 H2O (EC 2.5.1.72)
ABID97_RS07415 +0.4
Nicotinate-nucleotide diphosphorylase (carboxylating) (in reverse):
quinolinate + 2 H+ + 5-phospho-α-D-ribose 1-diphosphate→β-nicotinate D-ribonucleotide + CO2 + diphosphate (EC 2.4.2.19)
ABID97_RS07410 +0.2
Nicotinate-nucleotide adenylyltransferase:
β-nicotinate D-ribonucleotide + ATP + H+→nicotinate adenine dinucleotide + diphosphate (EC 2.7.7.18)
ABID97_RS16725 N.D.
NAD(+) synthase (glutamine-hydrolyzing):
nicotinate adenine dinucleotide + ATP + L-glutamine + H2O→NAD+ + AMP + L-glutamate + diphosphate + H+ (EC 6.3.5.1)
ABID97_RS00405 -1.5
ABID97_RS14845 +0.8
NAD(+) synthase:
nicotinate adenine dinucleotide + ammonium + ATP→NAD+ + AMP + diphosphate + H+ (EC 6.3.1.5)
ABID97_RS00405 -1.5
ABID97_RS05495 +0.0
ABID97_RS14845 +0.8

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information