MetaCyc Pathway: superpathway of pyridoxal 5'-phosphate biosynthesis and salvage in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

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Reactions and Genes LB_plus_SM_buffer with FelixO1_phage (wt new) 0.075 MOI
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1-deoxy-D-xylulose-5-phosphate synthase:
D-glyceraldehyde 3-phosphate + pyruvate + H+→1-deoxy-D-xylulose 5-phosphate + CO2 (EC 2.2.1.7)
GFF4324 N.D.
Erythrose-4-phosphate dehydrogenase:
D-erythrose 4-phosphate + NAD+ + H2O→4-phospho-D-erythronate + NADH + 2 H+ (EC 1.2.1.72)
GFF3022 -1.5
GFF3478 N.D.
Pyridoxal kinase:
pyridoxamine + ATP→pyridoxamine 5'-phosphate + ADP + H+ (EC 2.7.1.35)
GFF2050 -0.7
GFF3638 -0.2
Pyridoxine 4-dehydrogenase (in reverse):
pyridoxal + NADPH + H+→pyridoxine + NADP+ (EC 1.1.1.65)
No genes
Pyridoxal kinase:
pyridoxal + ATP→pyridoxal 5'-phosphate + ADP + H+ (EC 2.7.1.35)
GFF2050 -0.7
GFF3638 -0.2
4-phosphoerythronate dehydrogenase:
4-phospho-D-erythronate + NAD+→(3R)-3-hydroxy-2-oxo-4 phosphooxybutanoate + NADH + H+ (EC 1.1.1.290)
GFF1936 -2.7
Pyridoxal 5'-phosphate synthase:
pyridoxamine 5'-phosphate + dioxygen + H2O→pyridoxal 5'-phosphate + ammonium + hydrogen peroxide (EC 1.4.3.5)
GFF3636 N.D.
GFF4602 +0.1
Pyridoxal kinase:
pyridoxine + ATP→pyridoxine 5'-phosphate + ADP + H+ (EC 2.7.1.35)
GFF2050 -0.7
GFF3638 -0.2
Phosphoserine transaminase (in reverse):
(3R)-3-hydroxy-2-oxo-4 phosphooxybutanoate + L-glutamate→4-phosphooxy-L-threonine + 2-oxoglutarate (EC 2.6.1.52)
GFF3664 -1.7
4-hydroxythreonine-4-phosphate dehydrogenase:
4-phosphooxy-L-threonine + NAD+→3-amino-1-hydroxyacetone 1-phosphate + CO2 + NADH (EC 1.1.1.262)
GFF110 +2.2
GFF189 -2.3
Pyridoxine 5'-phosphate synthase:
3-amino-1-hydroxyacetone 1-phosphate + 1-deoxy-D-xylulose 5-phosphate→pyridoxine 5'-phosphate + H+ + phosphate + 2 H2O (EC 2.6.99.2)
GFF2472 N.D.
Pyridoxal 5'-phosphate synthase:
pyridoxine 5'-phosphate + dioxygen→pyridoxal 5'-phosphate + hydrogen peroxide (EC 1.4.3.5)
GFF3636 N.D.
GFF4602 +0.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information