MetaCyc Pathway: mixed acid fermentation in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

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Reactions and Genes LB_plus_SM_buffer with FelixO1_phage (wt new) 0.75 MOI
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Phosphoenolpyruvate carboxylase (in reverse):
phosphoenolpyruvate + hydrogen carbonate→oxaloacetate + phosphate (EC 4.1.1.31)
GFF2342 +0.0
Pyruvate kinase (in reverse):
phosphoenolpyruvate + ADP + H+→pyruvate + ATP (EC 2.7.1.40)
GFF1633 +1.5
GFF3567 +3.2
GFF3582 +0.6
D-lactate dehydrogenase (in reverse):
pyruvate + NADH + H+→(R)-lactate + NAD+ (EC 1.1.1.28)
GFF2638 -0.2
GFF3812 +0.1
Malate dehydrogenase (in reverse):
oxaloacetate + NADH + H+→(S)-malate + NAD+ (EC 1.1.1.37; 1.1.1.38)
GFF2149 -0.4
GFF2556 +0.5
GFF3033 -0.0
Formate C-acetyltransferase (in reverse):
pyruvate + coenzyme A→acetyl-CoA + formate (EC 2.3.1.54)
GFF2101 N.D.
GFF2337 -0.0
GFF2338 -0.5
GFF3207 -0.3
GFF3656 -0.4
GFF3660 +0.1
GFF722 +0.2
GFF723 +0.1
Acetaldehyde dehydrogenase (acetylating) (in reverse):
acetyl-CoA + NADH + H+→acetaldehyde + coenzyme A + NAD+ (EC 1.2.1.10)
GFF2078 +0.2
GFF2749 -0.2
Citrate (Si)-synthase:
acetyl-CoA + oxaloacetate + H2O→citrate + coenzyme A + H+ (EC 2.3.3.1; 2.3.3.16; 2.3.3.3)
GFF4634 -1.4
formate + H+→CO2 + H2
GFF1462 +0.0
GFF4715 -0.3
GFF4716 -0.2
GFF4717 +0.2
Fumarate hydratase:
(S)-malate→fumarate + H2O (EC 4.2.1.2)
GFF10 N.D.
GFF1477 -0.1
GFF1806 -0.5
GFF1807 +0.8
GFF3577 -0.3
GFF9 N.D.
Phosphate acetyltransferase:
acetyl-CoA + phosphate→acetyl phosphate + coenzyme A (EC 2.3.1.8)
GFF1901 +3.5
GFF2081 +0.4
GFF3938 -0.0
Acetate kinase (in reverse):
acetyl phosphate + ADP→acetate + ATP (EC 2.7.2.1; 2.7.2.15)
GFF1628 -0.3
GFF1900 +3.8
GFF2083 -0.0
GFF2084 N.D.
GFF3208 +0.2
GFF3928 +0.1
Aconitate hydratase:
citrate→cis-aconitate + H2O (EC 4.2.1.3)
GFF115 -1.5
GFF2709 -0.2
Alcohol dehydrogenase (in reverse):
acetaldehyde + NADH + H+→ethanol + NAD+ (EC 1.1.1.1)
GFF2132 +0.1
GFF2262 +0.1
GFF2557 -0.0
GFF2617 -0.0
GFF2749 -0.2
GFF957 -0.0
Succinate dehydrogenase (ubiquinone):
fumarate[in] + a menaquinol→succinate[in] + a menaquinone (EC 1.3.5.1)
GFF1996 -0.1
GFF1997 -0.3
GFF1998 -0.4
GFF1999 -0.2
Aconitate hydratase:
cis-aconitate + H2O→D-threo-isocitrate (EC 4.2.1.3)
GFF115 -1.5
GFF2709 -0.2
Isocitrate dehydrogenase (NADP(+)):
D-threo-isocitrate + NADP+→CO2 + 2-oxoglutarate + NADPH (EC 1.1.1.42)
GFF3422 N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information