MetaCyc Pathway: superpathway of C1 compounds oxidation to CO2 in Escherichia coli BW25113

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Reactions and Genes 3-methyl-3-butenol 0.31 vol%
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Methane monooxygenase:
methane + NAD(P)H + dioxygen + H+→methanol + NAD(P)+ + H2O (EC 1.14.13.25)
No genes
methylamine + 2 an oxidized amicyanin + H2O→formaldehyde + ammonium + 2 H+ + 2 a reduced amicyanin (EC 1.4.9.1)
No genes
methanol + 2 an oxidized cytochrome cL→formaldehyde + 2 a reduced cytochrome cL + 2 H+ (EC 1.1.2.7; 1.1.2.e)
No genes
Formaldehyde dehydrogenase:
formaldehyde + NAD+ + H2O→formate + NADH + 2 H+ (EC 1.2.1.46)
No genes
formaldehyde + tetrahydromethanopterin→5,10-methylene-tetrahydromethanopterin + H2O (EC 4.2.1.147)
No genes
S-(hydroxymethyl)glutathione synthase (in reverse):
formaldehyde + glutathione→S-(hydroxymethyl)glutathione (spontaneous) (EC 4.4.1.22)
No genes
5,10-methylene-tetrahydromethanopterin + NAD(P)+→5,10-methenyltetrahydromethanopterin + NAD(P)H
No genes
S-(hydroxymethyl)glutathione dehydrogenase:
S-(hydroxymethyl)glutathione + NAD(P)+→S-formylglutathione + NAD(P)H + H+ (EC 1.1.1.284)
b0356 (frmA) -2.0
Methenyltetrahydromethanopterin cyclohydrolase:
5,10-methenyltetrahydromethanopterin + H2O→5-formyl-tetrahydromethanopterin + H+ (EC 3.5.4.27)
No genes
S-formylglutathione hydrolase:
S-formylglutathione + H2O→formate + glutathione + H+ (EC 3.1.2.12)
b0355 (frmB) -0.6
b2154 (yeiG) -0.3
5-formyl-tetrahydromethanopterin + H2O→formate + H+ + tetrahydromethanopterin
No genes
formate + NAD+→CO2 + NADH (EC 1.17.1.9)
b1476 (fdnI) -0.1
b1499 (ydeO) +0.1
b1501 (YdeP) +0.1
b3892 (fdoI) -0.2
b3893 (fdoH) -0.1
b3895 (fdhD) -0.2

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information