MetaCyc Pathway: 4-oxopentanoate degradation in Pseudomonas putida KT2440

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Reactions and Genes L-Phenylalanine 5 mM (C)
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Butyrate--CoA ligase:
4-oxopentanoate + ATP + coenzyme A→4-oxopentanoyl-CoA + AMP + diphosphate (EC 6.2.1.2)
PP_2795 -0.3
PP_3553 +0.1
Butyrate--CoA ligase:
4-hydroxypentanoate + ATP + coenzyme A→4-hydroxypentanoyl-CoA + AMP + diphosphate (EC 6.2.1.2)
PP_2795 -0.3
PP_3553 +0.1
4-oxopentanoyl-CoA + NAD(P)H + H+→4-hydroxypentanoyl-CoA + NAD(P)+ (EC 1.1.1.M44)
PP_2794 +0.1
4-hydroxypentanoyl-CoA + ATP→4-(phosphooxy)pentanoyl-CoA + ADP + H+ (EC 2.7.1.M16)
PP_2791 -0.1
PP_2792 N.D.
4-(phosphooxy)pentanoyl-CoA→3-pentenoyl-CoA + phosphate (EC 5.4.4.M2)
No genes
3-pentenoyl-CoA→(2E)-pent-2-enoyl-CoA (EC 5.4.4.M2)
No genes
(2E)-pent-2-enoyl-CoA + H2O→(3R)-3-hydroxypentanoyl-CoA (EC 5.4.4.M2)
No genes
Acetoacetyl-CoA reductase:
(3R)-3-hydroxypentanoyl-CoA + NADP+→3-oxopentanoyl-CoA + NADPH + H+ (EC 1.1.1.36)
No genes
Acetyl-CoA C-acyltransferase (in reverse):
3-oxopentanoyl-CoA + coenzyme A→propanoyl-CoA + acetyl-CoA (EC 2.3.1.16; 2.3.1.9)
PP_0582 -0.0
PP_1377 -2.8
PP_2051 -0.1
PP_2137 -0.1
PP_2215 +0.3
PP_3280 -0.3
PP_3355 +0.2
PP_3754 -0.0
PP_4636 -0.0

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information