MetaCyc Pathway: superpathway of L-tyrosine biosynthesis in Pseudomonas putida KT2440

Reactions and Genes	mixed (C)s Trisodium citrate 10 mM and L-Meta-tyrosine 10 mM
3-deoxy-7-phosphoheptulonate synthase: D-erythrose 4-phosphate + phosphoenolpyruvate + H2O→3-deoxy-D-arabino-heptulosonate 7-phosphate + phosphate (EC 2.5.1.54)
PP_1866	-2.1
PP_2324	-2.1
PP_3080	-0.8
3-dehydroquinate synthase: 3-deoxy-D-arabino-heptulosonate 7-phosphate→3-dehydroquinate + phosphate (EC 4.2.3.4)
PP_5078	N.D.
3-dehydroquinate dehydratase: 3-dehydroquinate→3-dehydroshikimate + H2O (EC 4.2.1.10)
PP_0560	N.D.
PP_1612	N.D.
PP_2407	N.D.
PP_3003	-0.0
Shikimate dehydrogenase (in reverse): 3-dehydroshikimate + NADPH + H+→shikimate + NADP+ (EC 1.1.1.25)
PP_0074	N.D.
PP_2406	+0.1
PP_2608	+0.5
PP_3002	-0.1
PP_3768	+0.3
Shikimate kinase: shikimate + ATP→shikimate 3-phosphate + ADP + H+ (EC 2.7.1.71)
PP_5079	N.D.
3-phosphoshikimate 1-carboxyvinyltransferase: shikimate 3-phosphate + phosphoenolpyruvate→5-enolpyruvoyl-shikimate 3-phosphate + phosphate (EC 2.5.1.19)
PP_1770	-0.2
Chorismate synthase: 5-enolpyruvoyl-shikimate 3-phosphate→chorismate + phosphate (EC 4.2.3.5)
PP_1830	N.D.
Chorismate mutase: chorismate→prephenate (EC 5.4.99.5)
PP_1769	N.D.
Prephenate dehydrogenase: prephenate + NAD+→3-(4-hydroxyphenyl)pyruvate + CO2 + NADH (EC 1.3.1.12)
PP_1770	-0.2
Aspartate transaminase (in reverse): 3-(4-hydroxyphenyl)pyruvate + L-glutamate→L-tyrosine + 2-oxoglutarate (EC 2.6.1.1; 2.6.1.27; 2.6.1.5; 2.6.1.57)
PP_0486	-0.1
PP_0858	-0.1
PP_0967	-1.5
PP_1109	-0.2
PP_1872	+0.1
PP_1972	+0.2
PP_2642	-0.1
PP_2948	+0.1
PP_3544	-0.0
PP_3590	-2.2
PP_3750	-0.0
PP_3786	-0.2
PP_4197	-0.3
PP_5275	-0.0
PP_5342	-0.1

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information