MetaCyc Pathway: L-tyrosine degradation I in Pseudomonas putida KT2440

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Reactions and Genes mixed (C)s Trisodium citrate 10 mM and 3-Chloro-L-tyrosine 10 mM
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Aspartate transaminase:
L-tyrosine + 2-oxoglutarate→3-(4-hydroxyphenyl)pyruvate + L-glutamate (EC 2.6.1.1; 2.6.1.27; 2.6.1.5; 2.6.1.57)
PP_0486 -0.1
PP_0858 +0.0
PP_0967 -0.7
PP_1109 -0.0
PP_1872 -0.3
PP_1972 -0.4
PP_2642 -0.1
PP_2948 +0.2
PP_3544 -0.2
PP_3590 -3.3
PP_3750 +0.2
PP_3786 -0.3
PP_4197 -0.7
PP_5275 -0.0
PP_5342 +0.1
4-hydroxyphenylpyruvate dioxygenase:
3-(4-hydroxyphenyl)pyruvate + dioxygen→homogentisate + CO2 (EC 1.13.11.27)
PP_2554 -0.1
PP_3433 -1.3
Homogentisate 1,2-dioxygenase:
homogentisate + dioxygen→4-maleyl-acetoacetate + H+ (EC 1.13.11.5)
PP_4621 -0.7
Maleylacetoacetate isomerase:
4-maleyl-acetoacetate→4-fumaryl-acetoacetate (EC 5.2.1.2)
PP_4619 -2.1
Fumarylacetoacetase:
4-fumaryl-acetoacetate + H2O→acetoacetate + fumarate + H+ (EC 3.7.1.2)
PP_4620 -3.7

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information