MetaCyc Pathway: TCA cycle VI (Helicobacter) in Escherichia coli HS(pFamp)R (ATCC 700891)

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Reactions and Genes Phage Lil 1
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2-oxoglutarate synthase:
2-oxoglutarate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster→succinyl-CoA + CO2 + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster (EC 1.2.7.3)
No genes
3-oxoacid CoA-transferase:
succinyl-CoA + acetoacetate→succinate + acetoacetyl-CoA (EC 2.8.3.5)
No genes
Succinate dehydrogenase (ubiquinone) (in reverse):
succinate[in] + a menaquinone→fumarate[in] + a menaquinol (EC 1.3.5.1)
OHPLBJKB_03886 +0.3
OHPLBJKB_03887 +0.1
OHPLBJKB_03888 +0.2
OHPLBJKB_03889 +0.1
Fumarate hydratase (in reverse):
fumarate + H2O→(S)-malate (EC 4.2.1.2)
OHPLBJKB_00787 -0.3
OHPLBJKB_02049 +0.3
OHPLBJKB_02114 -1.4
OHPLBJKB_02115 -0.3
OHPLBJKB_03922 -0.1
(S)-malate + a menaquinone→oxaloacetate + a menaquinol (EC 1.1.5.4)
OHPLBJKB_01500 -0.2
Citrate (Si)-synthase:
oxaloacetate + acetyl-CoA + H2O→citrate + coenzyme A + H+ (EC 2.3.3.1; 2.3.3.16; 2.3.3.3)
OHPLBJKB_02997 -0.2
Aconitate hydratase:
citrate→cis-aconitate + H2O (EC 4.2.1.3)
OHPLBJKB_02406 +0.0
OHPLBJKB_02942 +0.0
OHPLBJKB_03543 -2.7
Aconitate hydratase:
cis-aconitate + H2O→D-threo-isocitrate (EC 4.2.1.3)
OHPLBJKB_02406 +0.0
OHPLBJKB_02942 +0.0
OHPLBJKB_03543 -2.7
Isocitrate dehydrogenase (NADP(+)):
D-threo-isocitrate + NADP+→2-oxoglutarate + CO2 + NADPH (EC 1.1.1.42)
OHPLBJKB_02532 N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information