MetaCyc Pathway: superpathway of L-threonine biosynthesis in Pseudomonas fluorescens GW456-L13

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Reactions and Genes D-Serine (N)
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Aspartate transaminase (in reverse):
oxaloacetate + L-glutamate→L-aspartate + 2-oxoglutarate (EC 2.6.1.1)
PfGW456L13_2059 +0.1
PfGW456L13_2142 -0.7
PfGW456L13_2252 -1.2
PfGW456L13_2943 -0.1
PfGW456L13_2947 +0.3
PfGW456L13_3163 +0.0
PfGW456L13_3206 -0.2
PfGW456L13_3261 +0.1
PfGW456L13_3292 +0.1
PfGW456L13_3363 +0.1
PfGW456L13_4175 -0.1
PfGW456L13_4396 -0.0
PfGW456L13_4856 +0.0
PfGW456L13_4919 -0.2
PfGW456L13_4930 -0.0
PfGW456L13_733 -0.1
PfGW456L13_807 -0.1
Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP (EC 2.7.2.4)
PfGW456L13_1981 -3.1
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate (EC 1.2.1.11)
PfGW456L13_3943 -0.1
PfGW456L13_3944 N.D.
PfGW456L13_4598 -0.9
Homoserine dehydrogenase (in reverse):
L-aspartate 4-semialdehyde + NAD(P)H + H+→L-homoserine + NAD(P)+ (EC 1.1.1.3)
PfGW456L13_1723 N.D.
Homoserine kinase:
L-homoserine + ATP→O-phospho-L-homoserine + ADP + H+ (EC 2.7.1.39)
PfGW456L13_3746 +0.5
PfGW456L13_4124 +0.2
PfGW456L13_596 N.D.
Threonine synthase:
O-phospho-L-homoserine + H2O→L-threonine + phosphate (EC 4.2.3.1)
PfGW456L13_1724 N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information