MetaCyc Pathway: L-citrulline biosynthesis in Pseudomonas fluorescens GW456-L13

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Reactions and Genes D-Serine (N)
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Arginase:
L-arginine + H2O→L-ornithine + urea (EC 3.5.3.1)
No genes
Glutamate synthase (NADPH):
L-glutamine + H2O→L-glutamate + ammonia + H+ (EC 1.4.1.13; 1.4.1.14; 1.4.7.1; 2.6.1.85; 3.5.1.2; 3.5.1.38; 4.1.3.27; 4.3.2.10; 4.3.3.6; 6.3.4.2; 6.3.5.13; 6.3.5.2; 6.3.5.4; 6.3.5.5; 6.3.5.6; 6.3.5.7)
PfGW456L13_1217 -4.9
PfGW456L13_1220 -3.0
PfGW456L13_1310 +0.3
PfGW456L13_1714 -0.8
PfGW456L13_1784 -0.9
PfGW456L13_1947 +0.3
PfGW456L13_2154 +0.1
PfGW456L13_2223 -1.5
PfGW456L13_2547 -0.2
PfGW456L13_271 -4.8
PfGW456L13_272 -5.2
PfGW456L13_3117 +0.2
PfGW456L13_3507 +0.4
PfGW456L13_3622 -0.1
PfGW456L13_3652 +0.1
PfGW456L13_3742 -0.2
PfGW456L13_3914 -0.1
PfGW456L13_4123 +0.0
PfGW456L13_4145 -1.9
PfGW456L13_4227 -0.3
PfGW456L13_4364 -0.1
PfGW456L13_4595 +0.1
PfGW456L13_4688 N.D.
PfGW456L13_4785 -0.1
PfGW456L13_4817 N.D.
PfGW456L13_5034 N.D.
PfGW456L13_5035 N.D.
PfGW456L13_5036 N.D.
PfGW456L13_5099 N.D.
PfGW456L13_5100 N.D.
L-proline[in] + an electron-transfer quinone→(S)-1-pyrroline-5-carboxylate[in] + an electron-transfer quinol + H+[in] (EC 1.5.5.2)
PfGW456L13_223 +0.3
Glutamate 5-kinase:
L-glutamate + ATP→γ-L-glutamyl 5-phosphate + ADP (EC 2.7.2.11)
PfGW456L13_1472 -5.9
(S)-1-pyrroline-5-carboxylate + H+ + H2O→L-glutamate 5-semialdehyde (spontaneous)
No genes
Glutamate-5-semialdehyde dehydrogenase (in reverse):
γ-L-glutamyl 5-phosphate + NADPH + H+→L-glutamate 5-semialdehyde + NADP+ + phosphate (EC 1.2.1.41)
PfGW456L13_1356 -0.9
PfGW456L13_3571 -0.2
Ornithine aminotransferase (in reverse):
L-glutamate + L-glutamate 5-semialdehyde→L-ornithine + 2-oxoglutarate (EC 2.6.1.13)
PfGW456L13_1971 +0.1
Ornithine carbamoyltransferase:
L-ornithine + carbamoyl phosphate→L-citrulline + H+ + phosphate (EC 2.1.3.3)
PfGW456L13_1739 -4.5
PfGW456L13_1873 +0.3

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information