MetaCyc Pathway: mevalonate pathway III (Thermoplasma) in Pseudomonas fluorescens GW456-L13

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Reactions and Genes L-Isoleucine (N)
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Acetyl-CoA C-acyltransferase:
2 acetyl-CoA→acetoacetyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)
PfGW456L13_2157 +0.1
PfGW456L13_2411 -0.2
PfGW456L13_2430 -0.1
PfGW456L13_2498 -0.1
PfGW456L13_2538 -0.0
PfGW456L13_2539 -0.3
PfGW456L13_29 -0.0
PfGW456L13_2982 -2.4
PfGW456L13_3394 +0.0
PfGW456L13_3408 -0.1
PfGW456L13_4040 -0.1
PfGW456L13_4147 +0.2
PfGW456L13_4590 +0.8
Hydroxymethylglutaryl-CoA synthase:
acetoacetyl-CoA + acetyl-CoA + H2O→(S)-3-hydroxy-3-methylglutaryl-CoA + coenzyme A + H+ (EC 2.3.3.10)
No genes
Hydroxymethylglutaryl-CoA reductase (NADPH) (in reverse):
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+→(R)-mevalonate + coenzyme A + 2 NADP+ (EC 1.1.1.34)
No genes
(R)-mevalonate + ATP→(R)-mevalonate 3-phosphate + ADP + H+ (EC 2.7.1.185)
No genes
(R)-mevalonate 3-phosphate + ATP→(R)-3,5-bisphosphomevalonate + ADP + H+ (EC 2.7.1.186)
No genes
(R)-3,5-bisphosphomevalonate + H+→3-methylbut-3-en-1-yl phosphate + CO2 + phosphate (EC 4.1.1.110)
No genes
3-methylbut-3-en-1-yl phosphate + ATP→3-methylbut-3-en-1-yl diphosphate + ADP (EC 2.7.4.26)
No genes
Isopentenyl-diphosphate Delta-isomerase:
3-methylbut-3-en-1-yl diphosphate→prenyl diphosphate (EC 5.3.3.2)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information