MetaCyc Pathway: pyruvate fermentation to isobutanol (engineered) in Agrobacterium fabrum C58

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Reactions and Genes 2,6-diaminopimelic (N)
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Acetolactate synthase:
2 pyruvate + H+→(S)-2-acetolactate + CO2 (EC 2.2.1.6)
Atu2035 -0.6
Atu2036 -3.2
Atu2128 -1.1
Atu5123 +0.1
Ketol-acid reductoisomerase (in reverse):
(S)-2-acetolactate + NADPH + H+→(2R)-2,3-dihydroxy-3-methylbutanoate + NADP+ (EC 1.1.1.86)
Atu2019 N.D.
Dihydroxy-acid dehydratase:
(2R)-2,3-dihydroxy-3-methylbutanoate→3-methyl-2-oxobutanoate + H2O (EC 4.2.1.9)
Atu1918 N.D.
Atu2736 -0.1
Atu3219 -0.1
Atu3971 -0.1
Branched-chain-2-oxoacid decarboxylase:
3-methyl-2-oxobutanoate + H+→isobutanal + CO2 (EC 4.1.1.72)
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Alcohol dehydrogenase (in reverse):
isobutanal + NADH + H+→isobutanol + NAD+ (EC 1.1.1.1)
Atu0626 +0.2
Atu1557 -0.1
Atu1595 N.D.
Atu1670 -0.1
Atu2022 +0.1
Atu2138 +0.0
Atu2151 +0.1
Atu2528 +0.1
Atu4236 -0.0
Atu4289 -0.1
Atu5074 -0.0
Atu5138 +0.1
Atu5202 +0.1
Atu5240 N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information