MetaCyc Pathway: superpathway of rosmarinic acid biosynthesis in Agrobacterium fabrum C58

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Reactions and Genes L-Phenylalanine (N)
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Phenylalanine ammonia-lyase:
L-phenylalanine→trans-cinnamate + ammonium (EC 4.3.1.24; 4.3.1.25; 5.4.3.10)
No genes
Tyrosine 3-monooxygenase:
L-tyrosine + dioxygen + 5,6,7,8-tetrahydrobiopterin→L-dopa + a 4a-hydroxytetrahydrobiopterin (EC 1.14.16.2)
No genes
Aspartate transaminase:
L-tyrosine + 2-oxoglutarate→3-(4-hydroxyphenyl)pyruvate + L-glutamate (EC 2.6.1.1; 2.6.1.27; 2.6.1.5; 2.6.1.57)
Atu0235 -0.0
Atu0529 -1.1
Atu1011 +0.0
Atu1589 -0.7
Atu1848 -0.7
Atu2015 -0.2
Atu2196 N.D.
Atu3612 N.D.
Atu4266 +0.1
Atu4278 -0.0
Hydroxyphenylpyruvate reductase (in reverse):
3-(4-hydroxyphenyl)pyruvate + NAD(P)H + H+→(R)-3-(4-hydroxyphenyl)lactate + NAD(P)+ (EC 1.1.1.237)
Atu4507 -0.0
Dihydroxyphenylalanine transaminase:
L-dopa + 2-oxoglutarate→3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate (EC 2.6.1.49)
No genes
trans-cinnamate + dioxygen + a reduced [NADPH-hemoprotein reductase]→4-coumarate + an oxidized [NADPH-hemoprotein reductase] + H2O (EC 1.14.14.91)
No genes
4-coumarate--CoA ligase:
4-coumarate + ATP + coenzyme A→(E)-4-coumaroyl-CoA + AMP + diphosphate (EC 6.2.1.12)
No genes
Hydroxyphenylpyruvate reductase (in reverse):
3-(3,4-dihydroxyphenyl)pyruvate + NAD(P)H + H+→(R)-3-(3,4-dihydroxyphenyl)lactate + NAD(P)+ (EC 1.1.1.237)
Atu4507 -0.0
(R)-3-(4-hydroxyphenyl)lactate + (E)-4-coumaroyl-CoA→4-coumaroyl-4'-hydroxyphenyllactate + coenzyme A
No genes
Rosmarinate synthase:
(R)-3-(3,4-dihydroxyphenyl)lactate + (E)-caffeoyl-CoA→(R)-rosmarinate + coenzyme A (EC 2.3.1.140)
No genes
4-coumaroyl-4'-hydroxyphenyllactate + dioxygen + a reduced [NADPH-hemoprotein reductase]→caffeoyl-4'-hydroxyphenyllactate + an oxidized [NADPH-hemoprotein reductase] + H2O
No genes
4-coumaroyl-4'-hydroxyphenyllactate + dioxygen + a reduced [NADPH-hemoprotein reductase]→4-coumaroyl-3',4'-dihydroxyphenyllactate + an oxidized [NADPH-hemoprotein reductase] + H2O
No genes
caffeoyl-4'-hydroxyphenyllactate + dioxygen + a reduced [NADPH-hemoprotein reductase]→(R)-rosmarinate + an oxidized [NADPH-hemoprotein reductase] + H2O
No genes
4-coumaroyl-3',4'-dihydroxyphenyllactate + dioxygen + a reduced [NADPH-hemoprotein reductase]→(R)-rosmarinate + an oxidized [NADPH-hemoprotein reductase] + H2O
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information