MetaCyc Pathway: pyruvate fermentation to acetone in Pseudomonas fluorescens GW456-L13

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Reactions and Genes L-Lysine (N)
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Pyruvate synthase:
pyruvate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster→acetyl-CoA + CO2 + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster (EC 1.2.7.1)
No genes
Acetyl-CoA C-acyltransferase:
2 acetyl-CoA→acetoacetyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)
PfGW456L13_2157 +0.3
PfGW456L13_2411 -1.5
PfGW456L13_2430 +0.2
PfGW456L13_2498 -0.4
PfGW456L13_2538 +0.1
PfGW456L13_2539 +0.1
PfGW456L13_29 -0.0
PfGW456L13_2982 -0.6
PfGW456L13_3394 +0.3
PfGW456L13_3408 -0.2
PfGW456L13_4040 +0.1
PfGW456L13_4147 +0.1
PfGW456L13_4590 +0.3
Butyrate--acetoacetate CoA-transferase (in reverse):
acetoacetyl-CoA + butanoate→acetoacetate + butanoyl-CoA (EC 2.8.3.9)
No genes
Butyrate--acetoacetate CoA-transferase (in reverse):
acetoacetyl-CoA + acetate→acetoacetate + acetyl-CoA (EC 2.8.3.9)
No genes
Acetoacetate decarboxylase:
acetoacetate + H+→acetone + CO2 (EC 4.1.1.4)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information