MetaCyc Pathway: valproate β-oxidation in Agrobacterium fabrum C58

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Reactions and Genes L-Lysine (N)
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Butyrate--CoA ligase:
valproate + ATP + coenzyme A→valproyl-CoA + AMP + diphosphate (EC 6.2.1.2)
No genes
valproyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-2-propylpent-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.5)
No genes
Enoyl-CoA hydratase (in reverse):
(2E)-2-propylpent-2-enoyl-CoA + H2O→(3S)-3-hydroxy-2-propylpentanoyl-CoA (EC 4.2.1.17)
Atu0322 -0.8
Atu0503 +0.2
Atu0733 +0.1
Atu1417 +0.1
Atu3481 -0.2
Atu3505 -0.2
3-hydroxyacyl-CoA dehydrogenase:
(3S)-3-hydroxy-2-propylpentanoyl-CoA + NAD+→3-oxo-2-propylpentanoyl-CoA + NADH + H+ (EC 1.1.1.35)
Atu0503 +0.2
Atu1415 +0.0
Acetyl-CoA C-acyltransferase (in reverse):
3-oxo-2-propylpentanoyl-CoA + coenzyme A→pentanoyl-CoA + propanoyl-CoA (EC 2.3.1.16)
Atu0502 -0.0
Atu2769 -3.0
Atu3475 -0.2
Atu4549 -0.2
Atu4823 -0.3
pentanoyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-pent-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.1)
No genes
(2E)-pent-2-enoyl-CoA + H2O→(3S)-3-hydroxypentanoyl-CoA
No genes
3-hydroxyacyl-CoA dehydrogenase:
(3S)-3-hydroxypentanoyl-CoA + NAD+→3-oxopentanoyl-CoA + NADH + H+ (EC 1.1.1.35)
Atu0503 +0.2
Atu1415 +0.0
Acetyl-CoA C-acyltransferase (in reverse):
3-oxopentanoyl-CoA + coenzyme A→propanoyl-CoA + acetyl-CoA (EC 2.3.1.16; 2.3.1.9)
Atu0502 -0.0
Atu2769 -3.0
Atu3475 -0.2
Atu4549 -0.2
Atu4823 -0.3

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information