MetaCyc Pathway: pyruvate fermentation to butanol II (engineered) in Pontibacter actiniarum KMM 6156, DSM 19842

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Reactions and Genes m.b. D-Cycloserine 0.032 mg/ml
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Acetyl-CoA C-acyltransferase:
2 acetyl-CoA→acetoacetyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)
CA264_11830 +0.4
CA264_15045 +1.7
CA264_17720 +0.2
3-hydroxyacyl-CoA dehydrogenase (in reverse):
acetoacetyl-CoA + NADH + H+→(S)-3-hydroxybutanoyl-CoA + NAD+ (EC 1.1.1.35)
CA264_06590 +0.2
CA264_15050 +1.8
CA264_16105 +0.5
(S)-3-hydroxybutanoyl-CoA→crotonyl-CoA + H2O (EC 4.2.1.150)
CA264_00410 +1.3
CA264_10930 -0.9
CA264_14485 -0.1
CA264_18085 +0.2
Trans-2-enoyl-CoA reductase (NAD(+)) (in reverse):
crotonyl-CoA + NADH + H+→butanoyl-CoA + NAD+ (EC 1.3.1.44)
CA264_09015 +0.2
CA264_15035 +1.3
CA264_17640 +1.0
CA264_19045 -0.6
Butanal dehydrogenase (in reverse):
butanoyl-CoA + NAD(P)H + H+→1-butanal + coenzyme A + NAD(P)+ (EC 1.2.1.57)
No genes
1-butanal + NADH + H+→butan-1-ol + NAD+
CA264_07375 +0.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information